{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:02:36Z","timestamp":1792724556185,"version":"4.5.0"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722000010_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Negative symptoms are one of the most incapacitating features of Schizophrenia but their pathophysiology remains unclear. They have been linked to alterations in grey matter in several brain regions, but findings have been inconsistent. This may reflect the investigation of relatively small patient samples, and the confounding effects of chronic illness and exposure to antipsychotic medication. We sought to address these issues by investigating concurrently grey matter volumes (GMV) and cortical thickness (CTh) in a large sample of antipsychotic-na\u00efve or minimally treated patients with First-Episode Schizophrenia (FES).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722000010_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>T1-weighted structural MRI brain scans were acquired from 180 antipsychotic-na\u00efve or minimally treated patients recruited as part of the OPTiMiSE study. The sample was stratified into subgroups with (<jats:italic>N<\/jats:italic> = 88) or without (<jats:italic>N<\/jats:italic> = 92) Prominent Negative Symptoms (PMN), based on PANSS ratings at presentation. Regional GMV and CTh in the two groups were compared using Voxel-Based Morphometry (VBM) and FreeSurfer (FS). Between-group differences were corrected for multiple comparisons via Family-Wise Error (FWE) and Monte Carlo z-field simulation respectively at <jats:italic>p<\/jats:italic> &lt; 0.05 (2-tailed).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722000010_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The presence of PMN symptoms was associated with larger left inferior orbitofrontal volume (<jats:italic>p<\/jats:italic> = 0.03) and greater CTh in the left lateral orbitofrontal gyrus (<jats:italic>p<\/jats:italic> = 0.007), but reduced CTh in the left superior temporal gyrus (<jats:italic>p<\/jats:italic> = 0.009).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722000010_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The findings highlight the role of orbitofrontal and temporal cortices in the pathogenesis of negative symptoms of Schizophrenia. As they were evident in generally untreated FEP patients, the results are unlikely to be related to effects of previous treatment or illness chronicity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722000010","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T09:43:04Z","timestamp":1645695784000},"page":"3471-3479","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":24,"title":["Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex: the OPTiMiSE 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