{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:09:06Z","timestamp":1791403746129,"version":"4.3.3"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291722001052_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anhedonia \u2013 a diminished interest or pleasure in activities \u2013 is a core self-reported symptom of depression which is poorly understood and often resistant to conventional antidepressants. This symptom may occur due to dysfunction in one or more sub-components of reward processing: motivation, consummatory experience and\/or learning. However, the precise impairments remain elusive. Dissociating these components (ideally, using cross-species measures) and relating them to the subjective experience of anhedonia is critical as it may benefit fundamental biology research and novel drug development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291722001052_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using a battery of behavioural tasks based on rodent assays, we examined reward motivation (Joystick-Operated Runway Task, JORT; and Effort-Expenditure for Rewards Task, EEfRT) and reward sensitivity (Sweet Taste Test) in a non-clinical population who scored high (\n                      <jats:italic>N<\/jats:italic>\n                      = 32) or low (\n                      <jats:italic>N<\/jats:italic>\n                      = 34) on an anhedonia questionnaire (Snaith\u2013Hamilton Pleasure Scale).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291722001052_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the low anhedonia group, the high anhedonia group displayed marginal impairments in effort-based decision-making (EEfRT) and reduced reward sensitivity (Sweet Taste Test). However, we found no evidence of a difference between groups in physical effort exerted for reward (JORT). Interestingly, whilst the EEfRT and Sweet Taste Test correlated with anhedonia measures, they did not correlate with each other. This poses the question of whether there are subgroups within anhedonia; however, further work is required to directly test this hypothesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291722001052_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that anhedonia is a heterogeneous symptom associated with impairments in reward sensitivity and effort-based decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291722001052","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T03:57:22Z","timestamp":1652327842000},"page":"4324-4332","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":29,"title":["Objective measures of reward sensitivity and motivation in people with high\n                    <i>v.<\/i>\n                    low anhedonia"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0463-5516","authenticated-orcid":false,"given":"Chloe","family":"Slaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Penton-Voak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R.","family":"Munaf\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor J.","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma S. J.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"S0033291722001052_ref34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2696-09.2009"},{"key":"S0033291722001052_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.12.006"},{"key":"S0033291722001052_ref33","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-8-22"},{"key":"S0033291722001052_ref4","volume-title":"Manual for the Beck Depression Inventory-II","author":"Beck","year":"1996"},{"key":"S0033291722001052_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2018.07.001"},{"key":"S0033291722001052_ref41","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.167.1.99"},{"key":"S0033291722001052_ref27","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091379"},{"key":"S0033291722001052_ref21","volume-title":"Discovering statistics using IBM SPSS statistics: And sex and drugs and rock \u2018n\u2019 roll","author":"Field","year":"2005"},{"key":"S0033291722001052_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(87)90108-9"},{"key":"S0033291722001052_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.12.014"},{"key":"S0033291722001052_ref44","doi-asserted-by":"publisher","DOI":"10.1177\/2167702620949236"},{"key":"S0033291722001052_ref45","doi-asserted-by":"publisher","DOI":"10.1037\/a0028813"},{"key":"S0033291722001052_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0029-9"},{"key":"S0033291722001052_ref46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006598"},{"key":"S0033291722001052_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023178"},{"key":"S0033291722001052_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_5004"},{"key":"S0033291722001052_ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00052"},{"key":"S0033291722001052_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.06.006"},{"key":"S0033291722001052_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-019-09717-2"},{"key":"S0033291722001052_ref10","article-title":"A study of trait anhedonia in non-clinical Chinese samples: Evidence from the Chapman scales for physical and social anhedonia","volume":"7","author":"Chan","year":"2012","journal-title":"PLoS One"},{"key":"S0033291722001052_ref25","doi-asserted-by":"publisher","DOI":"10.1126\/science.134.3483.943"},{"key":"S0033291722001052_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20087"},{"key":"S0033291722001052_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.2139"},{"key":"S0033291722001052_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1573-9"},{"key":"S0033291722001052_ref39","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260046445"},{"key":"S0033291722001052_ref48","doi-asserted-by":"publisher","DOI":"10.1177\/0963721412474460"},{"key":"S0033291722001052_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.74"},{"key":"S0033291722001052_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/da.20690"},{"key":"S0033291722001052_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2005.01.016"},{"key":"S0033291722001052_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00060-2"},{"key":"S0033291722001052_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2020.09.014"},{"key":"S0033291722001052_ref14","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000443"},{"key":"S0033291722001052_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrp.2005.11.001"},{"key":"S0033291722001052_ref43","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01409"},{"key":"S0033291722001052_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.11.043"},{"key":"S0033291722001052_ref51","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187257"},{"key":"S0033291722001052_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(98)80048-5"},{"key":"S0033291722001052_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00233-9"},{"key":"S0033291722001052_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)00756-6"},{"key":"S0033291722001052_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.02.003"},{"key":"S0033291722001052_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(91)90040-V"},{"key":"S0033291722001052_ref49","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711001905"},{"key":"S0033291722001052_ref11","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.85.4.374"},{"key":"S0033291722001052_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20327"},{"key":"S0033291722001052_ref1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"S0033291722001052_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.004"},{"key":"S0033291722001052_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.06.012"},{"key":"S0033291722001052_ref37","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116681416"},{"key":"S0033291722001052_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.11.005"},{"key":"S0033291722001052_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.11.026"},{"key":"S0033291722001052_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00019-8"},{"key":"S0033291722001052_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2018.01.024"},{"key":"S0033291722001052_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.08.056"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291722001052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:36:00Z","timestamp":1730280960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291722001052\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0033291722001052"],"URL":"https:\/\/doi.org\/10.1017\/s0033291722001052","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.21.21265287","asserted-by":"object"}]},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}