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Med."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722002677_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Repetitive negative thinking (RNT), a cognitive process that encompasses past (rumination) and future (worry) directed thoughts focusing on negative experiences and the self, is a transdiagnostic construct that is especially relevant for major depressive disorder (MDD). Severe RNT often occurs in individuals with severe levels of MDD, which makes it challenging to disambiguate the neural circuitry underlying RNT from depression severity.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722002677_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We used a propensity score, i.e., a conditional probability of having high RNT given observed covariates to match high and low RNT individuals who are similar in the severity of depression, anxiety, and demographic characteristics. Of 148 MDD individuals, we matched high and low RNT groups (<jats:italic>n<\/jats:italic> = 50\/group) and used a data-driven whole-brain voxel-to-voxel connectivity pattern analysis to investigate the resting-state functional connectivity differences between the groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722002677_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There was an association between RNT and connectivity in the bilateral superior temporal sulcus (STS), an important region for speech processing including inner speech. High relative to low RNT individuals showed greater connectivity between right STS and bilateral anterior insular cortex (AI), and between bilateral STS and left dorsolateral prefrontal cortex (DLPFC). Greater connectivity in those regions was specifically related to RNT but not to depression severity.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722002677_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>RNT intensity is directly related to connectivity between STS and AI\/DLPFC. This might be a mechanism underlying the role of RNT in perceptive, cognitive, speech, and emotional processing. Future investigations will need to determine whether modifying these connectivities could be a treatment target to reduce RNT.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722002677","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T08:08:29Z","timestamp":1661933309000},"page":"5488-5499","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Intensity of repetitive negative thinking in depression is associated with greater functional connectivity between semantic processing and emotion regulation areas"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7606-1745","authenticated-orcid":false,"given":"Aki","family":"Tsuchiyagaito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella 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