{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:17:55Z","timestamp":1760347075099,"version":"3.40.5"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722002719_sec_a1\"><jats:title>Background<\/jats:title><jats:p>It remains unclear how SSRIs and other antidepressants are associated with the risk of repeated suicide attempts. We aimed to analyse the association between redeemed antidepressant prescriptions and the risk of repeated suicide attempts, hypothesising that antidepressant treatment is associated with increased risk of repeated suicide attempts.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722002719_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The study was based on Danish register data and a validated cohort of 1842 suicide attempts. We used three Cox regression models (crude, adjusted and propensity score matched) to analyse the data; these models included both static and dynamic time-dependent factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722002719_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>1842 individuals attempted suicide in the study period, with a total of 210 repeated attempts. Individuals redeeming antidepressant prescriptions were more likely to repeat a suicide attempt. All crude models showed all antidepressants to be significant risk factors (HR around 1.39), whereas all adjusted models showed all antidepressants to be insignificant risk factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722002719_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>We found no significant increased risk of repeated suicide attempts in individuals redeeming a prescription for any antidepressant (or only SSRIs) when considering the individuals' baseline risk of repetition. This study is based on validated suicide attempts, register data, and strong epidemiology designs, but it still has some limitations, and the results should be replicated and confirmed in other studies.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722002719","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T08:08:37Z","timestamp":1661933317000},"page":"5510-5517","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Risk of repeated suicide attempt after redeeming prescriptions for antidepressants: a register-based study in Denmark"],"prefix":"10.1017","volume":"53","author":[{"given":"Sarah Grube","family":"Jakobsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Petrea","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsebeth","family":"Stenager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-9506","authenticated-orcid":false,"given":"Erik","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"S0033291722002719_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2020-214611"},{"key":"S0033291722002719_ref9","first-page":"415","article-title":"Register for suicide attempts","volume":"51","author":"Christiansen","year":"2004","journal-title":"Danish Medical Bulletin"},{"key":"S0033291722002719_ref12","first-page":"1241","article-title":"Association of antidepressant use with adverse health outcomes: A systematic umbrella review","volume":"76","author":"Dragioti","year":"2019","journal-title":"Journal of the American Medical Association Psychiatry"},{"key":"S0033291722002719_ref22","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"S0033291722002719_ref5","unstructured":"Bille-Brahe, U. (1998). Suicidal behaviour in Europe. The situation in the 1990s. Retrieved from https:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0007\/239938\/E60709.pdf."},{"key":"S0033291722002719_ref2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012777"},{"key":"S0033291722002719_ref16","first-page":"58","article-title":"Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and trial sequential analysis","volume":"17","author":"Jakobsen","year":"2017","journal-title":"Boston Medical Center Psychiatry"},{"key":"S0033291722002719_ref15","article-title":"New generation antidepressants for depression in children and adolescents: A network meta-analysis","volume":"5","author":"Hetrick","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0033291722002719_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.06.016"},{"key":"S0033291722002719_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/00048670601172749"},{"key":"S0033291722002719_ref23","article-title":"Suicidality and aggression during antidepressant treatment: Systematic review and meta-analyses based on clinical study reports","volume":"352","author":"Sharma","year":"2016","journal-title":"British Medical Journal"},{"volume-title":"Survival analysis using SAS: A practical guide","year":"2010","author":"Allison","key":"S0033291722002719_ref1"},{"key":"S0033291722002719_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.08.020"},{"key":"S0033291722002719_ref28","article-title":"Pharmacological interventions for self-harm in adults","volume":"1","author":"Witt","year":"2021","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"S0033291722002719_ref21","doi-asserted-by":"publisher","DOI":"10.4103\/picr.PICR_35_19"},{"key":"S0033291722002719_ref24","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.048371"},{"key":"S0033291722002719_ref25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2880"},{"key":"S0033291722002719_ref20","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"S0033291722002719_ref7","unstructured":"Centre for Suicide Research. (2022). Register for Suicide and Suicide Attempt. Retrieved from http:\/\/statistik.selvmordsforskning.dk\/."},{"key":"S0033291722002719_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2011.02405.x"},{"key":"S0033291722002719_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"S0033291722002719_ref29","unstructured":"World Health Organization. (1986). Working Group on Preventive Practices in Suicide and Attempted Suicide, York, 22-26 September 1986. WHO Regional Office for Europe. Copenhagen."},{"key":"S0033291722002719_ref26","first-page":"e003247","article-title":"Suicide-related events in young people following prescription of SSRIs and other antidepressants: A self-controlled case series analysis","volume":"3","author":"Wijlaars","year":"2013","journal-title":"British Medical Journal Open"},{"key":"S0033291722002719_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/08039488.2015.1065291"},{"volume-title":"Clinical psychiatry","year":"1960","author":"Mayer-Gross","key":"S0033291722002719_ref18"},{"key":"S0033291722002719_ref27","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210394483"},{"key":"S0033291722002719_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811405098"},{"key":"S0033291722002719_ref19","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.181.3.193"},{"key":"S0033291722002719_ref4","first-page":"1725","article-title":"Risk factors for fatal and nonfatal repetition of suicide attempts: A literature review","volume":"9","author":"Beghi","year":"2013","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"S0033291722002719_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.03.001"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291722002719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:24:38Z","timestamp":1693995878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291722002719\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0033291722002719"],"URL":"https:\/\/doi.org\/10.1017\/s0033291722002719","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"type":"print","value":"0033-2917"},{"type":"electronic","value":"1469-8978"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}