{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:56:18Z","timestamp":1766138178379,"version":"3.40.5"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722003142_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Subjective response (SR) to antipsychotic medication is relevant for quality of life, adherence and recovery. Here, we evaluate (1) the extent of variation in SR in patients using a single antipsychotic; (2) the association between subjective and symptomatic response; and (3) predictors of SR.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003142_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Open-label, single treatment condition with amisulpride in 339 patients with a first episode of a schizophrenia spectrum disorder, at most minimally treated before inclusion. Patients were evaluated at baseline, before start with amisulpride and after four weeks of treatment with the Subjective Wellbeing under Neuroleptic scale, the Positive and Negative Syndrome Scale, and the Calgary Depression Scale for Schizophrenia.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003142_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>(1) 26.8% of the patients had a substantial favorable SR, and 12.4% of the patients experienced a substantial dysphoric SR during treatment with amisulpride. (2) Modest positive associations were found between SR and 4 weeks change on symptom subscales (<jats:italic>r<\/jats:italic> = 0.268\u20130.390, <jats:italic>p<\/jats:italic> values &lt; 0.001). (3) Baseline affective symptoms contributed to the prediction of subjective remission, demographic characteristics did not. Lower start dosage of amisulpride was associated with a more favorable SR (<jats:italic>r<\/jats:italic> = \u22120.215, <jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003142_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>We conclude that variation in individual proneness for an unfavorable SR is substantial and only modestly associated with symptomatic response. We need earlier identification of those most at risk for unfavorable SR and research into interventions to improve SR to antipsychotic medication in those at risk.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722003142","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T15:50:41Z","timestamp":1671119441000},"page":"5986-5991","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Optimizing subjective wellbeing with amisulpride in first episode schizophrenia or related disorders"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-7926","authenticated-orcid":false,"given":"Lieuwe","family":"de Haan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"van Tricht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floor","family":"van 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M.","family":"D\u00edaz-Caneja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Bobes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Garc\u00eda-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Leucht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"S0033291722003142_ref17","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1104"},{"key":"S0033291722003142_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00166-3"},{"key":"S0033291722003142_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv019"},{"key":"S0033291722003142_ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-992141"},{"key":"S0033291722003142_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2021.48"},{"key":"S0033291722003142_ref13","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0110"},{"key":"S0033291722003142_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.553"},{"key":"S0033291722003142_ref21","first-page":"133","article-title":"A 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The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}