{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:26:40Z","timestamp":1783535200880,"version":"3.55.0"},"reference-count":83,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722003269_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Binge eating disorder (BED) is a pernicious psychiatric disorder which is linked with broad medical and psychiatric morbidity, and obesity. While BED may be characterized by altered cortical morphometry, no evidence to date examined possible sex-differences in regional gray matter characteristics among those with BED. This is especially important to consider in children, where BED symptoms often emerge coincident with rapid gray matter maturation.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003269_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Pre-adolescent, 9\u201310-year old boys (<jats:italic>N<\/jats:italic> = 38) and girls (<jats:italic>N<\/jats:italic> = 33) with BED were extracted from the 3.0 baseline (Year 0) release of the Adolescent Brain Cognitive Development Study. We investigated sex differences in gray matter density (GMD) via voxel-based morphometry. Control sex differences were also assessed in age and body mass index and developmentally matched control children (boys <jats:italic>N<\/jats:italic> = 36; girls <jats:italic>N<\/jats:italic> = 38). Among children with BED, we additionally assessed the association between dorsolateral prefrontal (dlPFC) GMD and parent-reported behavioral approach and inhibition tendencies.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003269_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Girls with BED uniquely demonstrate diffuse clusters of <jats:italic>greater<\/jats:italic> GMD (<jats:italic>p<\/jats:italic> &lt; 0.05, Threshold Free Cluster Enhancement corrected) in the (i) left dlPFC (<jats:italic>p<\/jats:italic> = 0.003), (ii) bilateral dmPFC (<jats:italic>p<\/jats:italic> = 0.004), (iii) bilateral primary motor and somatosensory cortex (<jats:italic>p<\/jats:italic> = 0.0003) and (iv) bilateral precuneus (<jats:italic>p<\/jats:italic> = 0.007). Brain-behavioral associations suggest a unique negative correlation between GMD in the left dlPFC and behavioral approach tendencies among girls with BED.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003269_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Early-onset BED may be characterized by regional sex differences in terms of its underlying gray matter morphometry.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722003269","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T11:35:28Z","timestamp":1666956928000},"page":"6077-6089","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Sex differences in regional gray matter density in pre-adolescent binge eating disorder: a voxel-based morphometry study"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-2915","authenticated-orcid":false,"given":"Stuart B.","family":"Murray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel P.","family":"Diaz-Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"Duval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane A.","family":"Balkchyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrin J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle T.","family":"Ganson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Jann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"S0033291722003269_ref44","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29203"},{"key":"S0033291722003269_ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2012.00030"},{"key":"S0033291722003269_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.52"},{"key":"S0033291722003269_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22204"},{"key":"S0033291722003269_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.05.022"},{"key":"S0033291722003269_ref33","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111170"},{"key":"S0033291722003269_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2021.11.031"},{"key":"S0033291722003269_ref81","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.27"},{"key":"S0033291722003269_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2019.11.308"},{"key":"S0033291722003269_ref43","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.549928"},{"key":"S0033291722003269_ref13","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.67.2.319"},{"key":"S0033291722003269_ref2","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"S0033291722003269_ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2010.02.012"},{"key":"S0033291722003269_ref35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048107"},{"key":"S0033291722003269_ref75","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150335"},{"key":"S0033291722003269_ref80","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1352-3"},{"key":"S0033291722003269_ref55","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000291"},{"key":"S0033291722003269_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.57"},{"key":"S0033291722003269_ref20","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180108111532"},{"key":"S0033291722003269_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20068"},{"key":"S0033291722003269_ref69","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537962"},{"key":"S0033291722003269_ref62","first-page":"1","article-title":"Aberrant functional connectivity between reward and inhibitory control networks in pre-adolescent binge eating disorder","author":"Murray","year":"2022a","journal-title":"Psychological Medicine"},{"key":"S0033291722003269_ref52","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22897"},{"key":"S0033291722003269_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.07.004"},{"key":"S0033291722003269_ref45","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0111-z"},{"key":"S0033291722003269_ref59","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-021-01287-z"},{"key":"S0033291722003269_ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-020-01164-5"},{"key":"S0033291722003269_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4044"},{"key":"S0033291722003269_ref68","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0349-14.2014"},{"key":"S0033291722003269_ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022259"},{"key":"S0033291722003269_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21052"},{"key":"S0033291722003269_ref53","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10010056"},{"key":"S0033291722003269_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.eatbeh.2011.03.001"},{"key":"S0033291722003269_ref83","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22171"},{"key":"S0033291722003269_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.04.002"},{"key":"S0033291722003269_ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2019.05.009"},{"key":"S0033291722003269_ref38","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20162"},{"key":"S0033291722003269_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.09.028"},{"key":"S0033291722003269_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.03.033"},{"key":"S0033291722003269_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.03.001"},{"key":"S0033291722003269_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-015-9708-8"},{"key":"S0033291722003269_ref41","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-015-0056-0"},{"key":"S0033291722003269_ref77","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(200003)27:2<218::AID-EAT10>3.0.CO;2-1"},{"key":"S0033291722003269_ref71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076542"},{"key":"S0033291722003269_ref54","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181e06b83"},{"key":"S0033291722003269_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008045046-9.00421-6"},{"key":"S0033291722003269_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801171"},{"key":"S0033291722003269_ref74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01263.x"},{"key":"S0033291722003269_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/BF03339721"},{"key":"S0033291722003269_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.05.003"},{"key":"S0033291722003269_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.054"},{"key":"S0033291722003269_ref19","unstructured":"Culbert, K. M. , Sinclair, E. , Hildebrandt, B. A. , Burt, S. A. , Sisk, C. L. , & Klump, K. L. (2016). Perinatal testosterone exposure contributes to sex differences in risk for binge eating after pubertal onset: Evidence from animal and human paradigms. Presented at Int. Conf. Eat. Disord., May 7, San Francisco."},{"key":"S0033291722003269_ref46","first-page":"545","article-title":"Kiddie schedule for affective disorders and schizophrenia","volume":"36","author":"Kaufman","year":"1997","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"S0033291722003269_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2015.10.042"},{"key":"S0033291722003269_ref42","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa369"},{"key":"S0033291722003269_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/10640266.2019.1652474"},{"key":"S0033291722003269_ref32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3550-16.2017"},{"key":"S0033291722003269_ref66","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-016-0313-5"},{"key":"S0033291722003269_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.026"},{"key":"S0033291722003269_ref82","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21345"},{"key":"S0033291722003269_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.04.004"},{"key":"S0033291722003269_ref73","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24467"},{"key":"S0033291722003269_ref39","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20130"},{"key":"S0033291722003269_ref78","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.259"},{"key":"S0033291722003269_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.11.004"},{"key":"S0033291722003269_ref47","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032816-045309"},{"key":"S0033291722003269_ref61","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22592"},{"key":"S0033291722003269_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2017.08.001"},{"key":"S0033291722003269_ref56","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23019"},{"key":"S0033291722003269_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114473"},{"key":"S0033291722003269_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.06.008"},{"key":"S0033291722003269_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21626"},{"key":"S0033291722003269_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-3967-1"},{"key":"S0033291722003269_ref60","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22452"},{"key":"S0033291722003269_ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"S0033291722003269_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2475"},{"key":"S0033291722003269_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"S0033291722003269_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/jora.12408"},{"key":"S0033291722003269_ref57","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0569-8"},{"key":"S0033291722003269_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"S0033291722003269_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2017.10.010"},{"key":"S0033291722003269_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2004.11.010"},{"key":"S0033291722003269_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.03.046"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291722003269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T08:22:29Z","timestamp":1695630149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291722003269\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":83,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0033291722003269"],"URL":"https:\/\/doi.org\/10.1017\/s0033291722003269","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,28]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}