{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:28:29Z","timestamp":1790800109139,"version":"4.1.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313903"],"award-info":[{"award-number":["2017A030313903"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004300","name":"Senior Talent Foundation of Jiangsu University","doi-asserted-by":"publisher","award":["D2020042"],"award-info":[{"award-number":["D2020042"]}],"id":[{"id":"10.13039\/501100004300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722003567_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Previous studies have confirmed that miR-146a-5p overexpression suppresses neurogenesis, thereby enhancing depression-like behaviors. However, it remains unclear how miR-146a-5p dysregulation produces <jats:italic>in vivo<\/jats:italic> brain structural abnormalities in patients with major depressive disorder (MDD).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003567_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study, we combined cortical morphology analysis of magnetic resonance imaging (MRI) and miR-146a-5p quantification to investigate the neuropathological effect of miR-146a-5p on cortical thickness in MDD patients. Serum-derived exosomes that were considered to readily cross the blood-brain barrier and contain miR-146a-5p were isolated for miRNA quantification. Moreover, follow-up MRI scans were performed in the MDD patients after 6 weeks of antidepressant treatment to further validate the clinical relevance of the relationship between miR-146a-5p and brain structural abnormalities.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003567_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In total, 113 medication-free MDD patients and 107 matched healthy controls were included. Vertex-vise general linear model revealed miR-146a-5p-dependent cortical thinning in MDD patients compared with healthy individuals, i.e., overexpression of miR-146a-5p was associated with reduced cortical thickness in the left orbitofrontal cortex (OFC), anterior cingulate cortex, bilateral lateral occipital cortices (LOCs), etc. Moreover, this relationship between baseline miR-146a-5p and cortical thinning was nonsignificant for all regions in the patients who had received antidepressant treatment, and higher baseline miR-146a-5p expression was found to be related to greater longitudinal cortical thickening in the left OFC and right LOC.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003567_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study reveal a relationship between miR-146a-5p overexpression and cortical atrophy and thus may help specify the <jats:italic>in vivo<\/jats:italic> mediating effect of miR-146a-5p dysregulation on brain structural abnormalities in patients with MDD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722003567","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T09:12:44Z","timestamp":1669367564000},"page":"6253-6260","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":29,"title":["Reduced cerebral cortex thickness is related to overexpression of exosomal miR-146a-5p in medication-free patients with major depressive disorder"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-0360","authenticated-orcid":false,"given":"Yanjia","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-4685","authenticated-orcid":false,"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"S0033291722003567_ref23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2237"},{"key":"S0033291722003567_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.12.007"},{"key":"S0033291722003567_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.38"},{"key":"S0033291722003567_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720000434"},{"key":"S0033291722003567_ref3","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7691"},{"key":"S0033291722003567_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.07.002"},{"key":"S0033291722003567_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.01.005"},{"key":"S0033291722003567_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1078"},{"key":"S0033291722003567_ref17","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2021.0099"},{"key":"S0033291722003567_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.04.047"},{"key":"S0033291722003567_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.07.037"},{"key":"S0033291722003567_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.60"},{"key":"S0033291722003567_ref8","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2016.13.5.549"},{"key":"S0033291722003567_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117428"},{"key":"S0033291722003567_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.69"},{"key":"S0033291722003567_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.11.006"},{"key":"S0033291722003567_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.06.006"},{"key":"S0033291722003567_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15497"},{"key":"S0033291722003567_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.08.008"},{"key":"S0033291722003567_ref15","doi-asserted-by":"publisher","DOI":"10.1242\/dev.028548"},{"key":"S0033291722003567_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1803-x"},{"key":"S0033291722003567_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.03.021"},{"key":"S0033291722003567_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.9"},{"key":"S0033291722003567_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.06.013"},{"key":"S0033291722003567_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003660"},{"key":"S0033291722003567_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12633"},{"key":"S0033291722003567_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.209"},{"key":"S0033291722003567_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20563"},{"key":"S0033291722003567_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.005"}],"container-title":["Psychological 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The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}