{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:38:06Z","timestamp":1788910686588,"version":"build-2803163510"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"14","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291722003919_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Major depressive disorder (MDD) is a complex disorder with a significant public health burden. Depression remission is often associated with weight gain, a major risk factor for metabolic syndrome (MetS). The primary objective of our study was to assess prospectively the impact of response to antidepressant treatment on developing MetS in a sample of MDD patients with a current major depressive episode (MDE) and who are newly initiating their treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003919_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>In the 6-month prospective METADAP cohort, non-overweight patients, body mass index &lt;25 kg\/m<jats:sup>2<\/jats:sup>, with MDD and a current MDE were assessed for treatment response after 3 months of treatment, and incidence of MetS after 3 and 6 months of treatment. Outcome variables were MetS, number of MetS criteria, and each MetS criterion (high waist circumference, high blood pressure, high triglyceridemia, low high-density lipoprotein-cholesterolemia, and high fasting plasma glucose).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003919_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In total, 98\/169 patients (58%) responded to treatment after 3 months. A total of 2.7% (1\/38) developed MetS out of which 12.7% (10\/79) (<jats:italic>p<\/jats:italic> value &lt; 0.001) had responded to treatment after 3 months. The fixed-effect regression models showed that those who responded to treatment after 3 months of follow-up had an 8.6 times higher odds of developing MetS (odds ratio = 8.58, 95% confidence interval 3.89\u201318.93, <jats:italic>p<\/jats:italic> value &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291722003919_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Compared to non-responders, non-overweight patients who responded to treatment after 3 months of antidepressant treatment had a significantly higher risk of developing MetS during the 6 months of treatment. Psychiatrists and nurses should closely monitor the metabolic profile of their patients, especially those who respond to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291722003919","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T08:23:07Z","timestamp":1673425387000},"page":"6560-6569","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Non-overweight depressed patients who respond to antidepressant treatment have a higher risk of later metabolic syndrome: findings from the METADAP cohort"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-8088","authenticated-orcid":false,"given":"K.","family":"El Asmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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