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The literature search was conducted up until 20th October 2022.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723001733_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Sixty-two studies comprising data from 3744 siblings were included. The pooled mean percentage of depressive symptoms fell in the mild range at 15.71 (<jats:italic>k<\/jats:italic> = 28, <jats:italic>N<\/jats:italic> = 2187, 95% CI 12.99\u201318.43) and anxiety symptoms fell in the minimal range at 22.45 (<jats:italic>k<\/jats:italic> = 16, <jats:italic>N<\/jats:italic> = 1122, 95% CI 17.09\u201327.80). Moderator analyses indicate that siblings of people with a schizophrenia spectrum disorder experience greater depressive symptoms than siblings of people with other types of MI (<jats:italic>\u03b2<\/jats:italic> = \u221216.38, <jats:italic>p<\/jats:italic> &lt; 0.001). Qualitative findings suggest that individuals may be particularly vulnerable during their siblings\u2019 illness onset and times of relapse. Limited communication, confusion about MI, and the need to compensate may contribute to siblings\u2019 distress and\/or burden. Siblings\u2019 experience of wellbeing and caregiving were closely related.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723001733_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>This review highlights the complex psychological experience of siblings and the need for greater research and clinical support for this important yet often overlooked cohort.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291723001733","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T09:18:38Z","timestamp":1690276718000},"page":"6945-6964","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["Distress, burden, and wellbeing in siblings of people with mental illness: a mixed studies systematic review and 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