{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:38:35Z","timestamp":1783006715796,"version":"3.54.5"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"16","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291723001952_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Blood biomarkers of Alzheimer's disease (AD) may allow for the early detection of AD pathology in mild cognitive impairment (MCI) due to AD (MCI-AD) and as a co-pathology in MCI with Lewy bodies (MCI-LB). However not all cases of MCI-LB will feature AD pathology. Disease-general biomarkers of neurodegeneration, such as glial fibrillary acidic protein (GFAP) or neurofilament light (NfL), may therefore provide a useful supplement to AD biomarkers. We aimed to compare the relative utility of plasma A<jats:italic>\u03b2<\/jats:italic>42\/40, <jats:italic>p<\/jats:italic>-tau181, GFAP and NfL in differentiating MCI-AD and MCI-LB from cognitively healthy older adults, and from one another.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723001952_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Plasma samples were analysed for 172 participants (31 healthy controls, 48 MCI-AD, 28 possible MCI-LB and 65 probable MCI-LB) at baseline, and a subset (<jats:italic>n<\/jats:italic> = 55) who provided repeated samples after \u22651 year. Samples were analysed with a Simoa 4-plex assay for A<jats:italic>\u03b2<\/jats:italic>42, A<jats:italic>\u03b2<\/jats:italic>40, GFAP and NfL, and incorporated previously-collected <jats:italic>p<\/jats:italic>-tau181 from this same cohort.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723001952_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Probable MCI-LB had elevated GFAP (<jats:italic>p<\/jats:italic> &lt; 0.001) and NfL (<jats:italic>p<\/jats:italic> = 0.012) relative to controls, but not significantly lower A<jats:italic>\u03b2<\/jats:italic>42\/40 (<jats:italic>p<\/jats:italic> = 0.06). GFAP and <jats:italic>p<\/jats:italic>-tau181 were higher in MCI-AD than MCI-LB. GFAP discriminated all MCI subgroups, from controls (AUC of 0.75), but no plasma-based marker effectively differentiated MCI-AD from MCI-LB. NfL correlated with disease severity and increased with MCI progression over time (<jats:italic>p<\/jats:italic> = 0.011).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723001952_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Markers of AD and astrocytosis\/neurodegeneration are elevated in MCI-LB. GFAP offered similar utility to <jats:italic>p<\/jats:italic>-tau181 in distinguishing MCI overall, and its subgroups, from healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291723001952","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T11:53:47Z","timestamp":1690286027000},"page":"7865-7873","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-3150","authenticated-orcid":false,"given":"Calum 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}