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We hypothesized that positive psychosocial traits (e.g. social support, personality traits, optimism, gratitude) may buffer risk of HAC in veterans with greater polygenic liability for alcohol consumption (AC).<\/jats:p><\/jats:sec><jats:sec id=\"S003329172300199X_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Data were analyzed from 1323 European-American US veterans who participated in the National Health and Resilience in Veterans Study, a 10-year, nationally representative longitudinal study of US military veterans. PRS reflecting genome-wide risk for AC (AUDIT-C) was derived from a Million Veteran Program genome-wide association study (<jats:italic>N<\/jats:italic> = 200 680).<\/jats:p><\/jats:sec><jats:sec id=\"S003329172300199X_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Among the total sample, 328 (weighted 24.8%) had persistent HAC, 131 (weighted 9.9%) had new-onset HAC, 44 (weighted 3.3%) had remitted HAC, and 820 (weighted 62.0%) had no\/low AC over the 10-year study period. AUDIT-C PRS was positively associated with persistent HAC relative to no\/low AC [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI) = 1.23\u20131.67] and remitted HAC (RRR = 1.63, 95% CI = 1.07\u20132.50). Among veterans with higher AUDIT-C PRS, greater baseline levels of agreeableness and greater dispositional gratitude were inversely associated with persistent HAC.<\/jats:p><\/jats:sec><jats:sec id=\"S003329172300199X_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>AUDIT-C PRS was prospectively associated with persistent HAC over a 10-year period, and agreeableness and dispositional gratitude moderated this association. Clinical interventions designed to target these modifiable psychological traits may help mitigate risk of persistent HAC in veterans with greater polygenic liability for persistent HAC.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s003329172300199x","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:49:10Z","timestamp":1693306150000},"page":"7893-7901","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort 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