{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:05:22Z","timestamp":1784649922865,"version":"3.55.0"},"reference-count":70,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003495","name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","doi-asserted-by":"publisher","award":["Project: The Adaptive Mind"],"award-info":[{"award-number":["Project: The Adaptive Mind"]}],"id":[{"id":"10.13039\/501100003495","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291723002179_sec_a1\"><jats:title>Background<\/jats:title><jats:p>There are phenomenological similarities between social anxiety disorder (SAD) and posttraumatic stress disorder, such as a provoking aversive event, posttraumatic stress symptoms (e.g. intrusions) in response to these events and deficient (context-dependent) fear conditioning processes. This study investigated the neural correlates of context-dependent extinction recall and fear renewal in SAD, specifically in patients with intrusions in response to an etiologically relevant aversive social event.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723002179_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>During functional magnetic resonance imaging a two-day context-dependent fear conditioning paradigm was conducted in 54 patients with SAD and 54 healthy controls (HC). This included fear acquisition (context A) and extinction learning (context B) on one day, and extinction recall (context B) as well as fear renewal (contexts C and A) one day later. The main outcome measures were blood oxygen level-dependent responses in regions of interest and skin conductance responses.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723002179_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Patients with SAD showed reduced differential conditioned amygdala activation during extinction recall in the safe extinction context and during fear renewal in the acquisition context compared to HC. Patients with clinically relevant intrusions moreover exhibited hypoactivation of the ventromedial prefrontal cortex (vmPFC) during extinction learning, extinction recall, and fear renewal in a novel context, while amygdala activation more strongly decreased during extinction learning and increased during fear renewal in the acquisition context compared with patients without intrusions.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723002179_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our study provides first evidence that intrusions in SAD are associated with similar deficits in context-dependent regulation of conditioned fear via the vmPFC as previously demonstrated in posttraumatic stress disorder.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291723002179","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T06:34:33Z","timestamp":1691562873000},"page":"548-557","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Neural correlates of context-dependent extinction recall in social anxiety disorder: relevance of intrusions in response to aversive social experiences"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-9249","authenticated-orcid":false,"given":"Susanne","family":"Fricke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa J.","family":"Seinsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie K.","family":"Neudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaela I.","family":"Zehtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"S0033291723002179_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2007.08.011"},{"key":"S0033291723002179_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(99)00123-0"},{"key":"S0033291723002179_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.06.026"},{"key":"S0033291723002179_ref7","first-page":"69","volume-title":"Social Phobia: Diagnosis, Assessment, and Treatment","author":"Clark","year":"1995"},{"key":"S0033291723002179_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004056"},{"key":"S0033291723002179_ref33","first-page":"174","volume-title":"Oxford Library of psychology. 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