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Linked independent component analysis (LICA) and correlation analysis were applied to identify associations between local neuroimaging patterns across modalities (including gray matter volume, white matter integrity, and spontaneous functional activity) and clinical factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723002386_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>LICA identified eight multimodal neuroimaging patterns related to phenotypic variations, including three related to symptoms and diagnosis. One imaging pattern (IC9) that included both the amplitude of low-frequency fluctuation measure of spontaneous functional activity and white matter integrity measures correlated negatively with OCD diagnosis and diagnostic scales. Two imaging patterns (IC10 and IC27) correlated with compulsion symptoms: IC10 included primarily anatomical measures and IC27 included primarily functional measures. In addition, we identified imaging patterns associated with age, gender, and emotional expression across subjects.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723002386_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>We established that data fusion techniques can identify local multimodal neuroimaging patterns associated with OCD phenotypes. The results inform our understanding of the neurobiological underpinnings of compulsive behaviors and OCD diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291723002386","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:49:08Z","timestamp":1693306148000},"page":"710-720","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Local structural and functional MRI markers of compulsive behaviors and obsessive\u2013compulsive disorder diagnosis within striatum-based circuits"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4442-9349","authenticated-orcid":false,"given":"Chuanyong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangqiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiang","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jierong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Seger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"S0033291723002386_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.002"},{"key":"S0033291723002386_ref54","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"S0033291723002386_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"S0033291723002386_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00902-6"},{"key":"S0033291723002386_ref44","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01588-6"},{"key":"S0033291723002386_ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34367-6"},{"key":"S0033291723002386_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.023"},{"key":"S0033291723002386_ref74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","article-title":"Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI","volume":"29","author":"Zang","year":"2007","journal-title":"Brain and Development"},{"key":"S0033291723002386_ref1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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