{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:15:17Z","timestamp":1793646917611,"version":"4.5.1"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022294","name":"National Taiwan University Hospital Yunlin Branch","doi-asserted-by":"publisher","award":["NTUHYL109.A005"],"award-info":[{"award-number":["NTUHYL109.A005"]}],"id":[{"id":"10.13039\/501100022294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291723003355_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Somatic symptom disorders (SSD) and functional somatic syndromes (FSS) are often regarded as similar diagnostic constructs; however, whether they exhibit similar clinical outcomes, medical costs, and medication usage patterns has not been examined in nationwide data. Therefore, this study focused on analyzing SSD and four types of FSS (fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, functional dyspepsia).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291723003355_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population-based matched cohort study utilized Taiwan's National Health Insurance (NHI) claims database to investigate the impact of SSD\/FSS. The study included 2 615 477 newly diagnosed patients with SSD\/FSS and matched comparisons from the NHI beneficiary registry. Healthcare utilization, mortality, medical expenditure, and medication usage were assessed as outcome measures. Statistical analysis involved Cox regression models for hazard ratios, generalized linear models for comparing differences, and adjustment for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291723003355_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All SSD\/FSS showed significantly higher adjusted hazard ratios for psychiatric hospitalization and all-cause hospitalization compared to the control group. All SSD\/FSS exhibited significantly higher adjusted hazard ratios for suicide, and SSD was particularly high. All-cause mortality was significantly higher in all SSD\/FSS. Medical costs were significantly higher for all SSD\/FSS compared to controls. The usage duration of all psychiatric medications and analgesics was significantly higher in SSD\/FSS compared to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291723003355_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All SSD\/FSS shared similar clinical outcomes and medical costs. The high hazard ratio for suicide in SSD deserves clinical attention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291723003355","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T03:07:41Z","timestamp":1700449661000},"page":"1452-1460","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["Clinical outcomes, medical costs, and medication usage patterns of different somatic symptom disorders and functional somatic syndromes: a population-based study in Taiwan"],"prefix":"10.1017","volume":"54","author":[{"given":"Chi-Shin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Cheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5786-3366","authenticated-orcid":false,"given":"Wei-Lieh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"S0033291723003355_ref15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMp048078","article-title":"Culture and depression","volume":"351","author":"Kleinman","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"S0033291723003355_ref22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/YCO.0000000000000089","article-title":"The future of somatoform disorders: Somatic symptom disorder, bodily distress disorder or functional syndromes?","volume":"27","author":"Rief","year":"2014","journal-title":"Current Opinion in Psychiatry"},{"key":"S0033291723003355_ref4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jpsychores.2010.02.004","article-title":"One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders","volume":"68","author":"Fink","year":"2010","journal-title":"Journal of Psychosomatic Research"},{"key":"S0033291723003355_ref8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000484413","article-title":"Management of functional somatic syndromes and bodily distress","volume":"87","author":"Henningsen","year":"2018","journal-title":"Psychotherapy and Psychosomatics"},{"key":"S0033291723003355_ref18","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.jval.2019.06.010","article-title":"Propensity score weighting using overlap weights: A new method applied to regorafenib clinical data and a cost-effectiveness analysis","volume":"22","author":"Mlcoch","year":"2019","journal-title":"Value in Health"},{"key":"S0033291723003355_ref26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jpsychores.2010.01.008","article-title":"Chronic fatigue syndrome: Is it one discrete syndrome or many? 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Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}