{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:57:51Z","timestamp":1773867471860,"version":"3.50.1"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S003329172300346X_sec_a1\"><jats:title>Background<\/jats:title><jats:p>We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRS<jats:sub>SCZ<\/jats:sub>-specific or evident also for any polygenic risk for mental disorders, e.g. for major depression.<\/jats:p><\/jats:sec><jats:sec id=\"S003329172300346X_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Participants came from the population-based Young Finns Study (<jats:italic>n<\/jats:italic> = 2377). We calculated a polygenic risk score for schizophrenia (PRS<jats:sub>SCZ<\/jats:sub>) and for major depression (PRS<jats:sub>DEP<\/jats:sub>). Diagnoses of psychotic disorders were derived from the hospital care register. Social development from adolescence to middle age was measured by (a) perceived social support from friends, family, and a close other, (b) perceived sociability, and (c) family structure (partnership status, number of children, age of first-time parenthood).<\/jats:p><\/jats:sec><jats:sec id=\"S003329172300346X_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Among those without manifest psychoses, high PRS<jats:sub>SCZ<\/jats:sub> predicted lower experienced support from friends (<jats:italic>B<\/jats:italic> = \u22120.04, <jats:italic>p<\/jats:italic> = 0.009\u20130.035) and family (<jats:italic>B<\/jats:italic> = \u22120.04, <jats:italic>p<\/jats:italic> = 0.009\u20130.035) especially after early adulthood, and also lower perceived sociability (<jats:italic>B<\/jats:italic> = \u22120.05, <jats:italic>p<\/jats:italic> = 0.010\u20130.026). PRS<jats:sub>SCZ<\/jats:sub> was not related to family structure. PRS<jats:sub>DEP<\/jats:sub> did not predict any domain of social development.<\/jats:p><\/jats:sec><jats:sec id=\"S003329172300346X_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Individuals at high PRS<jats:sub>SCZ<\/jats:sub> (not converted to psychosis) seem to experience a lower preference to be with others over being alone. Individuals with high (<jats:italic>v.<\/jats:italic> low) PRS<jats:sub>SCZ<\/jats:sub> seem to have a similar family structure in terms of partnership status or number of children but, nevertheless, they experience less support from their family. Among those not converted to psychosis in a typical age period, high PRS<jats:sub>SCZ<\/jats:sub> may predict a \u2018later risk phase\u2019 and reduced functional resilience when approaching middle age.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s003329172300346x","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T10:03:22Z","timestamp":1701684202000},"page":"1589-1597","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Polygenic risk for schizophrenia predicting social trajectories in a general population 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