{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:11:25Z","timestamp":1794010285118,"version":"4.8.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291723003549_sec_a1\"><jats:title>Background<\/jats:title><jats:p>The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723003549_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Study 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (<jats:italic>N<\/jats:italic> = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (<jats:italic>N<\/jats:italic> = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, <jats:italic>N<\/jats:italic> = 15 matched patients served as DBT-only controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723003549_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Study 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291723003549_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291723003549","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T11:25:55Z","timestamp":1703244355000},"page":"1651-1660","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6488-3143","authenticated-orcid":false,"given":"Malte","family":"Zopfs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-6427","authenticated-orcid":false,"given":"Miroslava","family":"Jindrov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-6838","authenticated-orcid":false,"given":"Guy","family":"Gurevitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-3406","authenticated-orcid":false,"given":"Jackob N.","family":"Keynan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-4335","authenticated-orcid":false,"given":"Talma","family":"Hendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9005-0084","authenticated-orcid":false,"given":"Sarah","family":"Baumeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal-M.","family":"Aggensteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Cornelisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brandeis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-0821","authenticated-orcid":false,"given":"Christian","family":"Schmahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-7182","authenticated-orcid":false,"given":"Christian","family":"Paret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"S0033291723003549_ref3","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0140-6736(21)00476-1","article-title":"Borderline 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