{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:55:23Z","timestamp":1793858123159,"version":"4.6.1"},"reference-count":64,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291724000291_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Interactions between the endocannabinoid system (ECS) and neurotransmitter systems might mediate the risk of developing a schizophrenia spectrum disorder (SSD). Consequently, we investigated in patients with SSD and healthy controls (HC) the relations between (1) plasma concentrations of two prototypical endocannabinoids (N-arachidonoylethanolamine [anandamide] and 2-arachidonoylglycerol [2-AG]) and (2) striatal dopamine synthesis capacity (DSC), and glutamate and y-aminobutyric acid (GABA) levels in the anterior cingulate cortex (ACC). As anandamide and 2-AG might reduce the activity of these neurotransmitters, we hypothesized negative correlations between their plasma levels and the abovementioned neurotransmitters in both groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000291_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Blood samples were obtained from 18 patients and 16 HC to measure anandamide and 2-AG plasma concentrations. For all subjects, we acquired proton magnetic resonance spectroscopy scans to assess Glx (i.e. glutamate plus glutamine) and GABA + (i.e. GABA plus macromolecules) concentrations in the ACC. Ten patients and 14 HC also underwent [<jats:sup>18<\/jats:sup>F]F-DOPA positron emission tomography for assessment of striatal DSC. Multiple linear regression analyses were used to investigate the relations between the outcome measures.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000291_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A negative association between 2-AG plasma concentration and ACC Glx concentration was found in patients (<jats:italic>p<\/jats:italic> = 0.008). We found no evidence of other significant relationships between 2-AG or anandamide plasma concentrations and dopaminergic, glutamatergic, or GABAergic measures in either group.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000291_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our preliminary results suggest an association between peripheral 2-AG and ACC Glx levels in patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291724000291","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T08:15:52Z","timestamp":1708676152000},"page":"2189-2199","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Endocannabinoid levels in plasma and neurotransmitters in the brain: a preliminary report on patients with a psychotic disorder and healthy individuals"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-920X","authenticated-orcid":false,"given":"Carmen F. 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