{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:24:03Z","timestamp":1793877843504,"version":"4.7.0"},"reference-count":69,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/501100016120","name":"Departamento de Salud, Gobierno de Navarra","doi-asserted-by":"publisher","award":["18\/41"],"award-info":[{"award-number":["18\/41"]}],"id":[{"id":"10.13039\/501100016120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291724000576_sec_a1\"><jats:title>Background:<\/jats:title><jats:p>First-episode psychotic disorders comprise a heterogeneous phenotype with a complex etiology involving numerous common small-effect genetic variations and a wide range of environmental exposures. We examined whether a family of schizophrenia spectrum disorder (FH-Sz) interacts with an environmental risk score (ERS-Sz) regarding the outcome of patients with non-affective first episode psychosis (NAFEP).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000576_sec_a2\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>We included 288 patients with NAFEP who were evaluated after discharge from an intensive 2-year program. We evaluated three outcome measures: symptomatic remission, psychosocial functioning, and personal recovery. We analyzed the main and joint associations of a FH-Sz and the ERS-Sz on the outcomes by using the relative excess risk due to interaction (RERI) approach.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000576_sec_a3\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>A FH-Sz showed a significant association with poor symptomatic remission and psychosocial functioning outcomes, although there was no significant interaction between a FH-Sz and the ERS-Sz on these outcomes. The ERS-Sz did not show a significant association with poor symptomatic remission and psychosocial functioning outcomes, even though the magnitude of the interaction between ERS-Sz and FH-Sz with the later outcome was moderate (RERI = 6.89, 95% confidence interval \u221216.03 to 29.81). There was no association between a FH-Sz and the ERS-Sz and personal recovery.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000576_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>Our results provide further empirical support regarding the contribution of FH-Sz to poor symptomatic remission and poor psychosocial functioning outcomes in patients with NAFEP.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291724000576","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T08:17:50Z","timestamp":1710922670000},"page":"2435-2443","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Additive effects of a family history of schizophrenia spectrum disorders and an environmental risk score for the outcome of patients with non-affective first-episode psychosis"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0250-5718","authenticated-orcid":false,"given":"Manuel J.","family":"Cuesta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garc\u00eda de Jal\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"S\u00e1nchez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo 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