{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:53:43Z","timestamp":1775746423020,"version":"3.50.1"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071908;82120108014"],"award-info":[{"award-number":["82071908;82120108014"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. 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Non-negative matrix factorization (NMF) and<jats:italic>k<\/jats:italic>-means clustering were performed to parse heterogeneity of schizophrenia, and the consistency of subtyping results from two cohorts. was tested.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000667_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>This study identified a subtype of patients in FES participants (47.5%) that exhibited widespread methylation level alterations of genes enriched in immune cell activity and a significantly higher proportion of neutrophils. This clustering of FES patients was validated in LTS patients, with high correspondence in epigenetic and clinical features across two cohorts<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000667_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>In summary, this study demonstrated a subtype of schizophrenia patients across both FES and LTS cohorts, defined by widespread alterations in methylation profile of genes related to immune function and distinguishing clinical features. This finding illustrates the promise of novel treatment strategies targeting immune dysregulation for a subpopulation of schizophrenia patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291724000667","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T08:17:51Z","timestamp":1710922671000},"page":"2538-2546","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["A subtype of schizophrenia patients with altered methylation level of genes related to immune cell 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