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However, the dynamics of TCT learning as a function of training exercises and their impact on neurocognitive functioning and therapeutic outcomes are unknown.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000783_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Forty subjects (SZ, <jats:italic>n<\/jats:italic> = 21; healthy subjects (HS), <jats:italic>n<\/jats:italic> = 19) underwent comprehensive clinical, cognitive, and auditory assessments, including measurements of auditory processing speed (APS) at baseline and after 1-h of TCT. SZ patients additionally completed 30-hours of TCT and repeated assessments ~10\u201312 weeks later.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000783_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>SZ patients were deficient in APS at baseline (<jats:italic>d<\/jats:italic> = 0.96, <jats:italic>p<\/jats:italic> &lt; 0.005) relative to HS. After 1-h of TCT, analyses revealed significant main effects of diagnosis (<jats:italic>d<\/jats:italic> = 1.75, <jats:italic>p<\/jats:italic> = 0.002) and time (<jats:italic>d<\/jats:italic> = 1.04, <jats:italic>p<\/jats:italic> &lt; 0.001), and a <jats:italic>diagnosis<\/jats:italic> \u00d7 <jats:italic>time<\/jats:italic> interaction (<jats:italic>d<\/jats:italic> = 0.85, <jats:italic>p<\/jats:italic> = 0.02) on APS. APS learning effects were robust after 1-h in SZ patients (<jats:italic>d<\/jats:italic> = 1.47, <jats:italic>p<\/jats:italic> &lt; 0.001) and persisted throughout the 30-h of training. Baseline APS was associated with verbal learning gains after 30-h of TCT (<jats:italic>r<\/jats:italic> = 0.51, <jats:italic>p<\/jats:italic> = 0.02) in SZ.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724000783_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>TCT learning metrics may have prognostic utility and aid in the prospective identification of individuals likely to benefit from TCT. Future experimental medicine studies may advance predictive algorithms that enhance TCT-related clinical, cognitive and functional outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291724000783","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:26:17Z","timestamp":1712568377000},"page":"2669-2676","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Early auditory processing abnormalities alter individual learning trajectories and sensitivity to computerized cognitive training in schizophrenia"],"prefix":"10.1017","volume":"54","author":[{"given":"Juan L.","family":"Molina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash B.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Nungaray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Sprock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Attarha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Biagianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal R.","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Light","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"S0033291724000783_ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.554475"},{"key":"S0033291724000783_ref25","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220649"},{"key":"S0033291724000783_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nn1315"},{"key":"S0033291724000783_ref28","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.177901"},{"key":"S0033291724000783_ref14","unstructured":"First, M. , Spitzer, R. , Gibbon, M. , & Williams, J. 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