{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:39Z","timestamp":1786999599491,"version":"build-2736575974"},"reference-count":74,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"unspecified","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291724001909_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although numerous neuroimaging studies have depicted neural alterations in individuals with obsessive\u2013compulsive disorder (OCD), a psychiatric disorder characterized by intrusive cognitions and repetitive behaviors, the molecular mechanisms connecting brain structural changes and gene expression remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724001909_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study combined the Allen Human Brain Atlas dataset with neuroimaging data from the Meta-Analysis (ENIGMA) consortium and independent cohorts. Later, partial least squares regression and enrichment analysis were performed to probe the correlation between transcription and cortical thickness variation among adults with OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724001909_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cortical map of case-control differences in cortical thickness was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms preferentially expressed across different cell types and cortical layers. These genes were specifically expressed in brain tissue, spanning all cortical developmental stages. Protein\u2013protein interaction analysis revealed that these genes coded a network of proteins encompassing various highly interactive hubs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724001909_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study findings bridge the gap between neural structure and transcriptome data in OCD, fostering an integrative understanding of the potential biological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291724001909","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T01:25:14Z","timestamp":1728005114000},"page":"3469-3478","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Genetic and molecular correlates of cortical thickness alterations in adults with obsessive\u2013compulsive disorder: a transcription\u2013neuroimaging association analysis"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-3896","authenticated-orcid":false,"given":"Da","family":"Zhang","sequence":"first","affiliation":[{"name":"The Affiliated Brain Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Teng","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhao","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Nanjing Medical 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