{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:23:49Z","timestamp":1787505829610,"version":"build-2736575974"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"15","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291724002034_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Borderline personality disorder (BPD) is a debilitating condition characterized by pervasive instability across multiple major domains of functioning. The majority of persons with BPD engage in self-injury and up to 10% die by suicide \u2013 rendering persons with this condition at exceptionally elevated risk of comorbidity and premature mortality. Better characterization of clinical risk factors among persons with BPD who die by suicide is urgently needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724002034_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We examined patterns of medical and psychiatric diagnoses (1580 to 1700 Phecodes) among persons with BPD who died by suicide (\n                      <jats:italic>n<\/jats:italic>\n                      = 379) via a large suicide death data resource and biobank. In phenotype-based phenome-wide association tests, we compared these individuals to three other groups: (1) persons who died by suicide without a history of BPD (\n                      <jats:italic>n<\/jats:italic>\n                      = 9468), (2) persons still living with a history of BPD diagnosis (\n                      <jats:italic>n<\/jats:italic>\n                      = 280), and (3) persons who died by suicide with a different personality disorder (other PD\n                      <jats:italic>n<\/jats:italic>\n                      = 589).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724002034_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariable logistic regression models revealed that persons with BPD who died by suicide were more likely to present with co-occurring psychiatric diagnoses, and have a documented history of self-harm in the medical system prior to death, relative to suicides without BPD. Posttraumatic stress disorder was more elevated among those with BPD who died by suicide relative to the other PD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724002034_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found significant differences among persons with BPD who died by suicide and all other comparison groups. Such differences may be clinically informative for identifying high-risk subtypes and providing targeted intervention approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291724002034","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T04:18:03Z","timestamp":1731903483000},"page":"4150-4159","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic profiles among suicide decedents with and without borderline personality disorder"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-6602","authenticated-orcid":false,"given":"Erin A.","family":"Kaufman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-5446","authenticated-orcid":false,"given":"Hilary","family":"Coon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-6821","authenticated-orcid":false,"given":"Andrey A.","family":"Shabalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-8300","authenticated-orcid":false,"given":"Eric T.","family":"Monson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Staley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-9443","authenticated-orcid":false,"given":"Brooks R.","family":"Keeshin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-7007","authenticated-orcid":false,"given":"Anna R.","family":"Docherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-1160","authenticated-orcid":false,"given":"Amanda V.","family":"Bakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-7297","authenticated-orcid":false,"given":"Emily","family":"DiBlasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"S0033291724002034_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.109131"},{"key":"S0033291724002034_ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000363145"},{"key":"S0033291724002034_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pmh.1375"},{"key":"S0033291724002034_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2749"},{"key":"S0033291724002034_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kww112"},{"key":"S0033291724002034_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2021.114308"},{"key":"S0033291724002034_ref22","volume-title":"Cognitive-behavioral treatment of borderline personality disorder","author":"Linehan","year":"1993"},{"key":"S0033291724002034_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2007.10.007"},{"key":"S0033291724002034_ref34","unstructured":"US Census Data (2023). 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Retrieved November 27, 2023, from: http:\/\/ibis.health.utah.gov"},{"key":"S0033291724002034_ref26","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55060223"},{"key":"S0033291724002034_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-9608-3_26"},{"key":"S0033291724002034_ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s40479-018-0093-9"},{"key":"S0033291724002034_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.019"},{"key":"S0033291724002034_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/17456916221100464"},{"key":"S0033291724002034_ref2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biodatasci-122320-112352"},{"key":"S0033291724002034_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1047"},{"key":"S0033291724002034_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(99)00028-8"},{"key":"S0033291724002034_ref16","doi-asserted-by":"publisher","DOI":"10.1037\/a0029429"},{"key":"S0033291724002034_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153760"},{"key":"S0033291724002034_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001296"},{"key":"S0033291724002034_ref1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2022"},{"key":"S0033291724002034_ref27","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2007.58.9.1199"},{"key":"S0033291724002034_ref29","first-page":"39","article-title":"Borderline personality disorder in the medical setting: Suggestive behaviors, syndromes, and diagnoses","volume":"12","author":"Sansone","year":"2015","journal-title":"Innovations in Clinical Neuroscience"},{"key":"S0033291724002034_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.04.006"},{"key":"S0033291724002034_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723001745"},{"key":"S0033291724002034_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02892-7"},{"key":"S0033291724002034_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/2167702617745641"},{"key":"S0033291724002034_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2023.05.005"},{"key":"S0033291724002034_ref31","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.590"},{"key":"S0033291724002034_ref10","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000084"},{"key":"S0033291724002034_ref5","unstructured":"Centers for Disease Control and Prevention (2023, August 10). Suicide data and statistics. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}