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Med."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291724002575_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mental disorders and physical-health conditions frequently co-occur, impacting treatment outcomes. While most prior research has focused on single pairs of mental disorders and physical-health conditions, this study explores broader associations between multiple mental disorders and physical-health conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724002575_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Norwegian primary-care register, this population-based cohort study encompassed all 2 203 553 patients born in Norway from January 1945 through December 1984, who were full-time residents from January 2006 until December 2019 (14 years; 363 million person-months). Associations between seven mental disorders (sleep disturbance, anxiety, depression, acute stress reaction, substance-use disorders, phobia\/compulsive disorder, psychosis) and 16 physical-health conditions were examined, diagnosed according to the International Classification of Primary Care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724002575_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 112 mental-disorder\/physical-health condition pairs, 96% of associations yielded positive and significant ORs, averaging 1.41 and ranging from 1.05 (99.99% CI 1.00\u20131.09) to 2.38 (99.99% CI 2.30\u20132.46). Across 14 years, every mental disorder was associated with multiple different physical-health conditions. Across 363 million person-months, having any mental disorder was associated with increased subsequent risk of all physical-health conditions (HRs:1.40 [99.99% CI 1.35\u20131.45] to 2.85 [99.99% CI 2.81\u20132.89]) and vice versa (HRs:1.56 [99.99% CI 1.54\u20131.59] to 3.56 [99.99% CI 3.54\u20133.58]). Associations were observed in both sexes, across age groups, and among patients with and without university education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291724002575_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The breadth of associations between virtually every mental disorder and physical-health condition among patients treated in primary care underscores a need for integrated mental and physical healthcare policy and practice. This remarkable breadth also calls for research into etiological factors and underlying mechanisms that can explain it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291724002575","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T04:17:52Z","timestamp":1731903472000},"page":"4274-4286","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["Co-occurrence between mental disorders and physical diseases: a study of nationwide primary-care medical records"],"prefix":"10.1017","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0937-1946","authenticated-orcid":false,"given":"Matthew 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