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We adjusted for a number of covariates including sociodemographic measures, body mass index, childhood trauma, and tobacco smoking. We found evidence of a strong association between daily or near daily cannabis use and suPAR.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724002848_sec_a13\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>We did not find any associations between less frequent cannabis use and suPAR. We did not find evidence of an association between IL-6, TNF<jats:italic>\u03b1<\/jats:italic> or CRP, and cannabis use.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291724002848_sec_a14\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our finding that frequent cannabis use is strongly associated with suPAR, a biomarker of systemic chronic inflammation implicated in neurodevelopmental and neurodegenerative processes is novel. These findings may provide valuable insights into biological mechanisms by which cannabis affects the brain and impacts the risk of serious mental disorders.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291724002848","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:36:00Z","timestamp":1733729760000},"page":"4665-4675","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Cannabis use in youth is associated with chronic 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