{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T06:36:14Z","timestamp":1794638174634,"version":"4.9.1"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"unspecified","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S003329172400343X_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Little is known about the dose and pattern of moderate-to-vigorous physical activity (MVPA) to prevent depression. We aimed to assess the prospective association of dose and pattern of accelerometer-derived MVPA with the risk of diagnosed depression.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329172400343X_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>We included 74,715 adults aged 40\u201369 years from the UK Biobank cohort who were free of severe disease at baseline and participated in accelerometer measurements (mean age 55.2 years [SD 7.8]; 58% women). MVPA at baseline was derived through 1-week wrist-worn accelerometry. Diagnosed depression was defined by hospitalization with ICD-10 codes F32.0-F32.A. Restricted cubic splines and Cox regression determined the prospective association of dose and pattern of MVPA with the risk of incident depression.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329172400343X_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Over a median 7.9-year follow-up, there were 3,089 (4.1%) incident cases of depression. Higher doses of MVPA were curvilinearly associated with lower depression risk, with the largest minute-per-minute added benefits occurring between 5 (HR 0.99 [95% CI 0.96\u20130.99]) and 280 (HR 0.67 [95% CI 0.60\u20130.74]) minutes per week (reference: 0 MVPA minutes).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329172400343X_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>Regardless of pattern, higher doses of MVPA were associated with lower depression risk in a curvilinear manner, with the greatest incremental benefit per minute occurring during the first 4\u20135 h per week. Optimal benefits occurred around 15 h\/week.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s003329172400343x","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T09:02:07Z","timestamp":1738659727000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Optimal dose and pattern of physical activity to prevent diagnosed depression: prospective cohort study"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-8085","authenticated-orcid":false,"given":"Lars Louis","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-3429","authenticated-orcid":false,"given":"Rub\u00e9n","family":"L\u00f3pez-Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Kandola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"N\u00fa\u00f1ez-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez-Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"S003329172400343X_r6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004366.pub6"},{"key":"S003329172400343X_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.07.113"},{"key":"S003329172400343X_r4","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.4175"},{"key":"S003329172400343X_r5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266605"},{"key":"S003329172400343X_r26","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.0609"},{"key":"S003329172400343X_r17","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02007-3"},{"key":"S003329172400343X_r34","article-title":"Physical activity and depression and anxiety disorders: A systematic review of reviews and assessment of causality","volume":"2","author":"Wanjau","year":"2023","journal-title":"AJPM Focus"},{"key":"S003329172400343X_r3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1456"},{"key":"S003329172400343X_r19","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796019000180"},{"key":"S003329172400343X_r33","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"S003329172400343X_r1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-019-1083-3"},{"key":"S003329172400343X_r20","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwac246"},{"key":"S003329172400343X_r29","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17111194"},{"key":"S003329172400343X_r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2016.12.008"},{"key":"S003329172400343X_r16","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30034-1"},{"key":"S003329172400343X_r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.06.045"},{"key":"S003329172400343X_r2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"S003329172400343X_r27","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-5-56"},{"key":"S003329172400343X_r32","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-06001-7"},{"key":"S003329172400343X_r7","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-004-0007-y"},{"key":"S003329172400343X_r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2013.08.001"},{"key":"S003329172400343X_r10","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.2488"},{"key":"S003329172400343X_r11","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182a0595f"},{"key":"S003329172400343X_r22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx254"},{"key":"S003329172400343X_r9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169649"},{"key":"S003329172400343X_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.040"},{"key":"S003329172400343X_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.02.023"},{"key":"S003329172400343X_r8","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3841"},{"key":"S003329172400343X_r36","unstructured":"World Health Organization. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e2"}}