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The aim of this study was to identify subgroups of individuals from the intersectional relationship between these factors and examine differences between subgroups on clinical outcomes.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329172500008X_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A latent profile analysis was conducted on baseline data from the AVATAR2 trial (<jats:italic>n<\/jats:italic>\u00a0=\u00a0345), to identify statistically distinct subgroups of individuals with psychosis who hear distressing voices based on co-occurring patterns of trauma, fearful attachment, and voice appraisals. The association between profile membership and demographic characteristics, voice severity, posttraumatic stress disorder symptoms, emotional distress, and difficulties with motivation and pleasure was then examined. Experts by experience were consulted throughout the process.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329172500008X_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Four profiles were identified: \u2018adverse voices and relational trauma\u2019, \u2018low malevolent and omnipotent voices\u2019, \u2018adverse voices yet low relational trauma\u2019, and \u2018high benevolent voices\u2019. Negative voice appraisals occurred in the presence of high and low trauma and attachment adversities. The first profile was associated with being female and\/or other non-male genders and had worse voice severity and emotional distress. High adversities and worse emotional distress occurred in the presence of voice benevolence and engagement. Black and South Asian ethnicities were not associated with specific profiles.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329172500008X_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>The identified profiles had negative and positive voice appraisals associated with higher and lower occurrence of adversities, and different clinical outcomes. These profiles could inform detailed case formulations that could tailor interventions for voice hearers.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s003329172500008x","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T09:07:38Z","timestamp":1740647258000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["The role of trauma, attachment, and voice-hearer\u2019s appraisals: a latent profile analysis in the AVATAR2 trial"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5112-2364","authenticated-orcid":false,"given":"Julia","family":"Marotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Montague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Fornells-Ambrojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"S003329172500008X_r37","volume-title":"Data Analysis with Mplus","author":"Geiser","year":"2013"},{"key":"S003329172500008X_r51","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu005"},{"key":"S003329172500008X_r59","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.032408.153506"},{"key":"S003329172500008X_r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.05.003"},{"key":"S003329172500008X_r29","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.148486"},{"key":"S003329172500008X_r28","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05797yel"},{"key":"S003329172500008X_r5","first-page":"1","article-title":"Auxiliary variables in mixture modeling: Using the BCH method in Mplus to estimate a distal outcome model and an arbitrary secondary model","volume":"21","author":"Asparouhov","year":"2021","journal-title":"Mplus web notes"},{"key":"S003329172500008X_r60","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/88.3.767"},{"key":"S003329172500008X_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2013.07.011"},{"key":"S003329172500008X_r22","unstructured":"Clark, S. 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