{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:37:33Z","timestamp":1794022653670,"version":"4.8.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"unspecified","delay-in-days":62,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0033291725000406_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Novel ultrasound neuromodulation techniques allow therapeutic brain stimulation with unmet precision and non-invasive targeting of deep brain areas. Transcranial pulse stimulation (TPS), a multifrequency sonication technique, is approved for the clinical treatment of Alzheimer\u2019s disease (AD). Here, we present the largest real-world retrospective analysis of ultrasound neuromodulation therapy in dementia (AD, vascular, mixed) and mild cognitive impairment (MCI).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000406_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>The consecutive sample involved 58 patients already receiving state-of-the-art treatment in an open-label, uncontrolled, retrospective study. TPS therapy typically comprises 10 sessions (range 8\u201312) with individualized MRI-based target areas defined according to brain pathology and individual pathophysiology. We compared the CERAD-Plus neuropsychological test battery results before and after treatment, with the CERAD Corrected Total Score ( CTS) as the primary outcome. Furthermore, we analyzed side effects reported by patients during the treatment period.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000406_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>CERAD Corrected Total Score (CTS) significantly improved (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.017, <jats:italic>d<\/jats:italic>\u00a0=\u00a0.32) after treatment (Baseline: <jats:italic>M<\/jats:italic>\u00a0=\u00a056.56, <jats:italic>SD<\/jats:italic>\u00a0=\u00a018.56; Post-treatment: <jats:italic>M<\/jats:italic>\u00a0=\u00a058.65, <jats:italic>SD<\/jats:italic>\u00a0=\u00a019.44). The group of top-responders (top quartile) improved even by 9.8 points. Fewer than one-third of all patients reported any sensation during treatment. Fatigue and transient headaches were the most common, with no severe adverse events.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000406_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>The findings implicate TPS as a novel and safe add-on therapy for patients with dementia or MCI with the potential to further improve current state-of-the-art treatment results. Despite the individual benefits, further randomized, sham-controlled, longitudinal clinical trials are needed to differentiate the effects of verum and placebo.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0033291725000406","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:34:11Z","timestamp":1741070051000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["A retrospective analysis of ultrasound neuromodulation therapy using transcranial pulse stimulation in 58 dementia patients"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-6933","authenticated-orcid":false,"given":"Sonja","family":"Radjenovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Grigoryeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mitterwallner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Osou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zettl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Plischek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lachmair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Herzhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Matt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Beisteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"S0033291725000406_r3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205634"},{"key":"S0033291725000406_r35","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-05906-2"},{"key":"S0033291725000406_r16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02289162"},{"key":"S0033291725000406_r21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62265-8"},{"key":"S0033291725000406_r29","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12101277"},{"key":"S0033291725000406_r23","article-title":"Effects of ultrasound neuromodulation with Transcranial Pulse Stimulation in Alzheimer\u2019s disease: A Randomized Clinical Trial","author":"Matt","year":"in press","journal-title":"JAMA Neurology"},{"key":"S0033291725000406_r25","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-12114-1"},{"key":"S0033291725000406_r19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291817"},{"key":"S0033291725000406_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102563"},{"key":"S0033291725000406_r31","doi-asserted-by":"publisher","DOI":"10.1159\/000357774"},{"key":"S0033291725000406_r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.02.018"},{"key":"S0033291725000406_r17","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16030360"},{"key":"S0033291725000406_r24","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1420255"},{"key":"S0033291725000406_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.06.005"},{"key":"S0033291725000406_r1","first-page":"337","article-title":"The effect of standardization on a \u03c7 2 approximation in factor analysis","volume":"38","author":"Bartlett","year":"1951","journal-title":"Biometrika"},{"key":"S0033291725000406_r5","article-title":"Transcranial Pulse Stimulation with Ultrasound in Alzheimer\u2019s Disease\u2014A New Navigated Focal Brain Therapy. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e70"}}