{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:50:03Z","timestamp":1793127003810,"version":"4.5.0"},"reference-count":69,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"unspecified","delay-in-days":135,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0033291725000492_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Binge-eating disorder (BED) is characterized by highly distressing episodes of loss-of-control over-eating. We have examined the use of repetitive transcranial magnetic stimulation (rTMS) for the treatment of people with BED and associated obesity. Such non-invasive brain stimulation (NIBS) techniques are used therapeutically in several psychiatric conditions and there is an associated scientific rationale.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000492_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Sixty participants were randomly allocated to receive 20 sessions of neuronavigated 10\u00a0Hz rTMS administered to the left dorsolateral prefrontal cortex (dlPFC) or sham treatment. Primary outcomes were the frequency of binge eating episodes (BEE) and the \u2018urge to eat\u2019 (craving) evaluated at baseline and end-of-treatment (8\u00a0weeks post-randomization). Secondary outcomes included body mass index (BMI), hunger, general and specific eating disorder psychopathology. Follow-up analyses were conducted for most outcomes at 16\u00a0weeks post-randomization. Multilevel models were used to evaluate group, time, and group-by-time interactions for the association between rTMS exposure and outcomes.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000492_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The real rTMS group (compared with sham treatment), showed a significantly greater decrease in the number of BEE at the end of treatment (Estimated Mean [EM]: 2.41 95% CI: 1.84\u20133.15 versus EM: 1.45 95% CI: 1.05\u20131.99, p\u00a0=\u00a00.02), and at follow-up (EM: 3.79 95% CI: 3\u20134.78 versus EM: 2.45 95% CI: 1.88\u20133.17, p\u00a0=\u00a00.02; group \u00d7 time interaction analysis p\u00a0=\u00a00.02). No group differences were found for other comparisons.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000492_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>rTMS was associated with reduced BEE during and after treatment: it suggests rTMS is a promising intervention for BED.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0033291725000492","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:46:49Z","timestamp":1747388809000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in binge eating disorder: a double-blind randomized controlled trial"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6687-8738","authenticated-orcid":false,"given":"Mara F.","family":"Maranh\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara","family":"Estella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisa G.","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain C.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica M.","family":"Claudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"S0033291725000492_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycr.2022.100055"},{"key":"S0033291725000492_r13","unstructured":"R Core Team. 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