{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:17:18Z","timestamp":1767093438647,"version":"3.40.2"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"unspecified","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0033291725000534_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Hallucinations are common and distressing symptoms in Parkinson\u2019s disease (PD). Treatment response in clinical trials is measured using validated questionnaires, including the Scale for Assessment of Positive Symptoms-Hallucinations (SAPS-H) and University of Miami PD Hallucinations Questionnaire (UM-PDHQ). The minimum clinically important difference (MCID) has not been determined for either scale. This study aimed to estimate a range of MCIDs for SAPS-H and UM-PDHQ using both consensus-based and statistical approaches.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000534_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A Delphi survey was used to seek opinions of researchers, clinicians, and people with lived experience. We defined consensus as agreement \u226575%. Statistical approaches used blinded data from the first 100 PD participants in the Trial for Ondansetron as Parkinson\u2019s Hallucinations Treatment (TOP HAT, NCT04167813). The distribution-based approach defined the MCID as 0.5 of the standard deviation of change in scores from baseline at 12\u00a0weeks. The anchor-based approach defined the MCID as the average change in scores corresponding to a 1-point improvement in clinical global impression-severity scale (CGI-S).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000534_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Fifty-one researchers and clinicians contributed to three rounds of the Delphi survey and reached consensus that the MCID was 2 points on both scales. Sixteen experts with lived experience reached the same consensus. Distribution-defined MCIDs were 2.6 points for SAPS-H and 1.3 points for UM-PDHQ, whereas anchor-based MCIDs were 2.1 and 1.3 points, respectively.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725000534_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>We used triangulation from multiple methodologies to derive the range of MCID estimates for the two rating scales, which was between 2 and 2.7 points for SAPS-H and 1.3 and 2 points for UM-PDHQ.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0033291725000534","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T12:30:28Z","timestamp":1742819428000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Minimal clinically important differences for treatment of hallucinations in Parkinson\u2019s disease and dementia with Lewy 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