{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:59:15Z","timestamp":1791039555922,"version":"4.1.0"},"reference-count":63,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"unspecified","delay-in-days":177,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["F-114842"],"award-info":[{"award-number":["F-114842"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0033291725100871_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Weight suppression represents the difference between highest and current body weight and predicts maintenance of bulimia nervosa and related syndromes (BN-S). This study tested a biobehavioral model of binge-eating severity in which greater weight suppression links to reduced leptin, which links to reduced glucagon-like peptide 1 (GLP-1) release, which links to both decreased reward satiation and increased reward valuation, which link, respectively, to excessive food intake and loss of control while eating \u2013 the defining features of DSM-5 binge-eating episodes.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725100871_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Women (<jats:italic>N<\/jats:italic>\u00a0=\u00a0399) who met DSM-5 criteria for bulimia nervosa or another eating disorder with binge eating (<jats:italic>n<\/jats:italic>\u00a0=\u00a0321) or had no lifetime eating disorder symptoms (<jats:italic>n<\/jats:italic>\u00a0=\u00a078) participated in a multi-visit protocol, including structured clinical interviews, height, weight, weight history, percent body fat, fasting leptin, post-prandial GLP-1 response to a fixed meal, and self-report and behavioral assessments of food reward satiation (<jats:italic>ad lib<\/jats:italic> meal) and food and nonfood reward valuation (progressive ratio tasks).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725100871_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>A structural equation model (SEM) demonstrated excellent fit to data with significant pathways from greater weight suppression to lower leptin, to blunted GLP-1 response, to lower reward satiation, to larger eating\/binge-eating episode size, with significant indirect paths through leptin, GLP-1, and reward satiation. SEM with paths via reward valuation to loss of control eating demonstrated inadequate fit.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0033291725100871_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Findings specifically link reduced GLP-1 response to severity of binge-episode size and support weight history assessment in eating disorders, DSM-5 over ICD-11 criteria for binge eating, and may inform future clinical trials of GLP-1 agonists for BN-S.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0033291725100871","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T10:25:27Z","timestamp":1751019927000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Test of a biobehavioral model linking weight suppression to binge-eating severity via leptin and glucagon-like peptide 1 in bulimia nervosa and related syndromes in women"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-5147","authenticated-orcid":false,"given":"Pamela K.","family":"Keel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-7762","authenticated-orcid":false,"given":"Lindsay P.","family":"Bodell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4604-7491","authenticated-orcid":false,"given":"Jonathan","family":"Appelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-7440","authenticated-orcid":false,"given":"Diana L.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"S0033291725100871_r17","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22264"},{"key":"S0033291725100871_r52","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.11.009"},{"key":"S0033291725100871_r29","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20738"},{"key":"S0033291725100871_r7","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000077"},{"key":"S0033291725100871_r42","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0955-2"},{"key":"S0033291725100871_r44","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20405"},{"key":"S0033291725100871_r63","doi-asserted-by":"publisher","DOI":"10.1113\/JP280581"},{"key":"S0033291725100871_r26","doi-asserted-by":"publisher","DOI":"10.4324\/9781315624358"},{"key":"S0033291725100871_r2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.252"},{"key":"S0033291725100871_r22","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/56.4.656"},{"key":"S0033291725100871_r27","doi-asserted-by":"publisher","DOI":"10.1080\/10705519909540118"},{"key":"S0033291725100871_r30","doi-asserted-by":"publisher","DOI":"10.2196\/66554"},{"key":"S0033291725100871_r36","doi-asserted-by":"publisher","DOI":"10.1037\/a0019190"},{"key":"S0033291725100871_r10","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20881"},{"key":"S0033291725100871_r43","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24210"},{"key":"S0033291725100871_r50","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000746"},{"key":"S0033291725100871_r38","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.9.1058"},{"key":"S0033291725100871_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.10.012"},{"key":"S0033291725100871_r20","volume-title":"Structured clinical interview for DSM-5 disorders\u2013research version (SCID-5-RV)","author":"First","year":"2014"},{"key":"S0033291725100871_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.03.009"},{"key":"S0033291725100871_r49","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2015.03.005"},{"key":"S0033291725100871_r13","article-title":"Leptin levels in acute and recovered eating disorders: An arm-based network meta-analysis","author":"Cassioli","year":"2024","journal-title":"European Eating Disorders Review"},{"key":"S0033291725100871_r37","doi-asserted-by":"publisher","DOI":"10.1037\/pas0001107"},{"key":"S0033291725100871_r58","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-019-0348-6"},{"key":"S0033291725100871_r60","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000814"},{"key":"S0033291725100871_r19","unstructured":"Fairbum, C. 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