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This study aimed to forward-translate this preclinical evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101268_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomised, double-blind, placebo-controlled study, 18 CHR-P individuals underwent resting-state functional magnetic resonance imaging twice, once following a 5\u00a0mg dose of diazepam and once following a placebo. They were compared to 20 healthy controls (HC) who did not receive diazepam\/placebo. Functional connectivity (FC) between the hippocampal CA1 subfield and the nucleus accumbens (NAc), amygdala, and ventromedial prefrontal cortex (vmPFC) was calculated. Mixed-effects models investigated the effect of group (CHR-P placebo\/diazepam vs. HC) and condition (CHR-P diazepam vs. placebo) on CA1-to-region FC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101268_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the placebo condition, CHR-P individuals showed significantly lower CA1-vmPFC (\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a03.17,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0=\u00a00.002) and CA1-NAc (\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a02.94,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0=\u00a00.005) FC compared to HC. In the diazepam condition, CA1-vmPFC FC was significantly increased (\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a04.13,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0=\u00a00.008) compared to placebo in CHR-P individuals, and both CA1-vmPFC and CA1-NAc FC were normalised to HC levels. In contrast, compared to HC, CA1-amygdala FC was significantly lower contralaterally and higher ipsilaterally in CHR-P individuals in both the placebo and diazepam conditions (lower: placebo\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a03.46,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0=\u00a00.002, diazepam\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a03.33,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0=\u00a00.003; higher: placebo\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a04.48,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0&lt;\u00a00.001, diazepam\n                      <jats:italic>Z<\/jats:italic>\n                      \u00a0=\u00a04.22,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101268_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that diazepam can partially restore hippocampal CA1 dysconnectivity in CHR-P individuals, suggesting that modulation of GABAergic function might be useful in the treatment of this clinical group.<\/jats:p>\n                  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