{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:28:59Z","timestamp":1785432539557,"version":"3.56.0"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"unspecified","delay-in-days":238,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 106-2314-B-002-106, 107-2314-B-002 -222 -MY3, 110-2314- B002-121-MY3, NSTC 113-2314-B-002-184-MY3"],"award-info":[{"award-number":["MOST 106-2314-B-002-106, 107-2314-B-002 -222 -MY3, 110-2314- B002-121-MY3, NSTC 113-2314-B-002-184-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291725101591_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with remitted psychosis, the dosage of antipsychotics can be lowered without increased risk of relapse. Whether dose tapering can lead to improved cognition is unclear. We compared changes in cognitive performance between patients undergoing dose tapering and those receiving a fixed maintenance dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101591_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 2-year prospective trial of patients with stable schizophrenia-related psychotic disorders was conducted: one group received guided dose reduction (GDR) and one group received maintenance treatment. Cognitive function was assessed using the Wechsler Adult Intelligence Scale-Third Edition, Mandarin Chinese version, at baseline, 1, and 2 years. The relations between the ratio of reduced dose and the extent of cognitive improvement were examined by Spearman\u2019s correlation coefficient. We also examined cognitive performance between aripiprazole (ARI) users and non-ARI users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101591_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GDR patients exhibited significantly greater improvements in total intellectual quotient (IQ), particularly working memory, and information and arithmetic subtest scores, with no significant difference in relapse rates between groups. Statistically significant dose\u2013response correlations were found between the degree of dose reduction and improvements in total IQ (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.242,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041), Working Memory Index (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.284,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016), and Arithmetic subtest (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.295,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012). There were no differences in cognitive changes between ARI users and non-users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101591_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lowering antipsychotic dosage may ameliorate patient performance in several cognitive domains. This finding is worthy of consideration while evaluating the risk-to-benefit ratio of tapering antipsychotics in patients with remitted psychosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291725101591","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:14:26Z","timestamp":1756300466000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Successful antipsychotic dose tapering leading to better cognition in patients with remitted psychosis: Results of Guided Antipsychotic Reduction to Reach Minimum Effective Dose (GARMED) trial"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-1940","authenticated-orcid":false,"given":"Chun-I","family":"Liu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National Taiwan University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Min","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National Taiwan University Hospital"},{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming H.","family":"Hsieh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National Taiwan University Hospital"},{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-4744","authenticated-orcid":false,"given":"Yi-Ting","family":"Lin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National Taiwan University Hospital"},{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-2414","authenticated-orcid":false,"given":"Yi-Ling","family":"Chien","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National Taiwan University Hospital"},{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-9484","authenticated-orcid":false,"given":"Tzung-Jeng","family":"Hwang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National Taiwan University Hospital"},{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Yen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"National 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e247"}}