{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:17:18Z","timestamp":1790705838273,"version":"4.1.0"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"unspecified","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S003329172510161X_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      After remission of a first-episode psychosis (FEP), antipsychotic discontinuation is associated with an increased risk of relapse compared to maintenance treatment. We studied short and longer-term effects of discontinuation of D\n                      <jats:sub>2<\/jats:sub>\n                      receptor (D\n                      <jats:sub>2<\/jats:sub>\n                      R) antagonist and partial agonist antipsychotics on striatal dopamine D\n                      <jats:sub>2\/3<\/jats:sub>\n                      R availability in FEP patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172510161X_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Remitted FEP patients underwent two [\n                      <jats:sup>11<\/jats:sup>\n                      C]raclopride PET scans to measure striatal D\n                      <jats:sub>2\/3<\/jats:sub>\n                      R availability: 1 week after antipsychotic discontinuation (n = 16 antagonist users, n = 6 partial agonist users) and after being medication free for 6\u20138 weeks (n = 8 antagonist users, n = 5 partial agonist users). Fifteen matched healthy controls were scanned once. Psychotic relapse was monitored up to 12 months after discontinuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172510161X_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One week after discontinuation, D\n                      <jats:sub>2<\/jats:sub>\n                      R antagonist discontinuers showed higher striatal binding potential (BP\n                      <jats:sub>ND<\/jats:sub>\n                      ) than partial D\n                      <jats:sub>2<\/jats:sub>\n                      R agonist discontinuers (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001, CI = 0.749 to 1.681) and controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045, CI = 0.008 to 0.708), while partial agonist discontinuers had significantly lower BP\n                      <jats:sub>ND<\/jats:sub>\n                      than controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001, CI = -1.326 to -0.386). 6-8 weeks after discontinuation, former antagonist users showed similar BP\n                      <jats:sub>ND<\/jats:sub>\n                      to controls (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.25), whereas former partial agonist users had higher BP\n                      <jats:sub>ND<\/jats:sub>\n                      than controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027, CI = 0.069 to 1.085). Participants who discontinued antagonists relapsed more often (81%) than those who discontinued partial agonists (17%)(\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 5.32,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172510161X_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Discontinuation of partial D\n                      <jats:sub>2<\/jats:sub>\n                      R agonists may affect D\n                      <jats:sub>2\/3<\/jats:sub>\n                      R availability differently than discontinuation of antagonists, which might explain the greater relapse risk after tapering antagonists than partial agonist antipsychotics.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s003329172510161x","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T08:13:58Z","timestamp":1757319238000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Dopamine D\n                    <sub>2\/3<\/sub>\n                    R availability after discontinuation of antipsychotic treatment: a [\n                    <sup>11<\/sup>\n                    C]raclopride PET study in remitted first-episode psychosis patients"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-0969","authenticated-orcid":false,"given":"Franciska","family":"de Beer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03cv38k47","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Groningen, University Medical Centre 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