{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:08:49Z","timestamp":1785424129111,"version":"3.56.0"},"reference-count":86,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"unspecified","delay-in-days":328,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF22OC0071010"],"award-info":[{"award-number":["NNF22OC0071010"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291725101839_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Shared genetic risk has been shown across psychiatric disorders. In particular, anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and schizophrenia (SCZ) show shared genetic risk that matches clinical evidence of shared illness and cognitive phenotypes. Given this evidence, we leveraged a large US-based population-based study to determine genetic associations of disorder-specific and shared psychiatric, cognitive, and brain markers and explore whether the latter might be state versus trait markers in eating disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101839_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used data from the population-based Philadelphia Neurodevelopmental Cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a04,729) and conducted sex-stratified analyses to test for associations between genetic risk for three disorders (AN, OCD, and SCZ) and mental health phenotypes, neurocognitive traits, and cortical features in a non-clinical population. Exploratory analyses on cortical features were run on a subset with neuroimaging data (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0626).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101839_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genetic risk for AN was significantly associated with body image distortion (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u00a0=\u00a00.02), and body image distortion was significantly related to a reduction in grey matter volume (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u00a0=\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725101839_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Genetic risk for AN associates with AN trait in a non-clinical sample of youth, particularly in females. Whilst genetic risk was not associated with cognitive or cortical markers, the AN phenotype was associated with cortical markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291725101839","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:16:56Z","timestamp":1764062216000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Genetic risk and transdiagnostic traits in anorexia nervosa, obsessive-compulsive disorder, and schizophrenia"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7732-2907","authenticated-orcid":false,"given":"Stefana","family":"Aicoboaie","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services CPH"},{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Pappaianni","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services CPH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdulkadir","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena L","family":"Davies","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services CPH"},{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-2273","authenticated-orcid":false,"given":"Nadia","family":"Micali","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services CPH"},{"id":[{"id":"https:\/\/ror.org\/047m0fb88","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Mental Health Services"},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"S0033291725101839_r7","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028956"},{"key":"S0033291725101839_r27","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10096"},{"key":"S0033291725101839_r38","first-page":"980","article-title":"Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data","volume":"36","author":"Kaufman","year":"1997","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"S0033291725101839_r55","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22918"},{"key":"S0033291725101839_r21","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852915000012"},{"key":"S0033291725101839_r45","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00742-5"},{"key":"S0033291725101839_r25","doi-asserted-by":"publisher","DOI":"10.1038\/nature07953"},{"key":"S0033291725101839_r74","doi-asserted-by":"publisher","DOI":"10.1002\/erv.1163"},{"key":"S0033291725101839_r79","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2017.00005"},{"key":"S0033291725101839_r71","doi-asserted-by":"publisher","DOI":"10.1002\/erv.784"},{"key":"S0033291725101839_r85","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0749-x"},{"key":"S0033291725101839_r1","first-page":"905","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5\u2122","year":"2013"},{"key":"S0033291725101839_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.09.005"},{"key":"S0033291725101839_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.02.016"},{"key":"S0033291725101839_r44","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0461-1"},{"key":"S0033291725101839_r81","unstructured":"World Health Organization. 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