{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:27:05Z","timestamp":1761643625702,"version":"build-2065373602"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"unspecified","delay-in-days":300,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["296785"],"award-info":[{"award-number":["296785"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-191702"],"award-info":[{"award-number":["PJT-191702"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291725102146_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anorexia nervosa has potential to influence the development and function of the gastrointestinal system. We assessed the association between maternal anorexia nervosa and risk of gastrointestinal morbidity in offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102146_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed a longitudinal cohort of 1,269,370 children born in Quebec, Canada, between 2006 and 2022. The exposure was maternal anorexia nervosa. The outcome was hospitalization for pediatric gastrointestinal disorders, including hypertrophic pyloric stenosis, inflammatory bowel disease, and other digestive morbidity. Follow-up ranged from 1 to 17\u00a0years. We used adjusted Cox regression models to obtain hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between maternal anorexia nervosa and pediatric gastrointestinal disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102146_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2,447 children (0.2%) had a mother with anorexia nervosa. By age 17\u00a0years, the cumulative incidence of gastrointestinal disorders was higher among children whose mothers had anorexia nervosa than other children (165.7 vs. 129.4 per 1,000). Compared with no anorexia, maternal anorexia nervosa was associated with a greater risk of any childhood gastrointestinal disorder (HR: 1.42, 95% CI: 1.26\u20131.61), particularly hypertrophic pyloric stenosis (HR: 2.51, 95% CI: 1.35\u20134.66), inflammatory bowel disease (HR: 2.46, 95% CI: 1.67\u20133.64), and rectal hemorrhage (HR: 3.46, 95% CI: 1.97\u20136.09). Children whose mothers developed anorexia nervosa after age 20\u00a0years or were hospitalized more than once for anorexia had the greatest risk of gastrointestinal morbidity. The associations were not explained by digestive birth defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102146_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal anorexia nervosa is associated with pediatric gastrointestinal disorders that could potentially be mitigated with psychosocial support, nutritional rehabilitation, and breastfeeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291725102146","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:23:46Z","timestamp":1761643426000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal morbidity in children whose mothers have anorexia nervosa: A longitudinal cohort study"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":false,"given":"Nathalie","family":"Auger","sequence":"first","affiliation":[{"name":"University of Montreal Hospital Research Centre"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec"},{"name":"University of Montreal"},{"name":"McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"Isra\u00ebl","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Steiger","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Low","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-2327","authenticated-orcid":false,"given":"Nicholas","family":"Chadi","sequence":"additional","affiliation":[{"name":"University of Montreal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2455-7845","authenticated-orcid":false,"given":"\u00c9milie","family":"Brousseau","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Centre"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3242-9392","authenticated-orcid":false,"given":"Gabriel","family":"C\u00f4t\u00e9-Corriveau","sequence":"additional","affiliation":[{"name":"University of Montreal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"S0033291725102146_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.10.012"},{"key":"S0033291725102146_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.03.064"},{"key":"S0033291725102146_r6","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13358"},{"key":"S0033291725102146_r18","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-015-0040-8"},{"key":"S0033291725102146_r33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2009.00208.x"},{"key":"S0033291725102146_r8","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-024-02393-y"},{"key":"S0033291725102146_r16","doi-asserted-by":"publisher","DOI":"10.1192\/apt.10.1.59"},{"key":"S0033291725102146_r5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01794944"},{"key":"S0033291725102146_r12","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.4974"},{"key":"S0033291725102146_r25","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.133"},{"key":"S0033291725102146_r13","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16459"},{"key":"S0033291725102146_r28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01281.x"},{"key":"S0033291725102146_r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.05.003"},{"key":"S0033291725102146_r34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-3010.2006.00541.x"},{"key":"S0033291725102146_r32","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0282-y"},{"key":"S0033291725102146_r27","first-page":"729","article-title":"Early 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(2024, April 29). People from visible minorities. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e324"}}