{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:01:43Z","timestamp":1781478103417,"version":"3.54.1"},"reference-count":62,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"unspecified","delay-in-days":301,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["#848041003 and #636340001"],"award-info":[{"award-number":["#848041003 and #636340001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S003329172510216X_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Evidence on psychological side effects (PSEs) of antipsychotic medication after remission from first-episode psychosis (FEP), and their momentary impact on daily life, is limited. This study examined how Dopamine-2 (D\n                      <jats:sub>2<\/jats:sub>\n                      ) affinity and antipsychotic dosage relate to momentary PSEs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172510216X_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This ecological momentary assessment (EMA) study included baseline data from 56 participants in the ongoing Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment (HAMLETT) trial. Momentary mental states indicative of reduced affect intensity, stability, and variability, as well as avolition and mental fatigue, were assessed 10\u00d7\/day for eight days (N\u00a0=\u00a03,005 data points). Since these PSEs may result from D\n                      <jats:sub>2<\/jats:sub>\n                      -receptor actions, antipsychotics were classified by receptor affinity and mechanism of action. Multilevel mixed-effects regression models examined serial cross-sectional associations between D\n                      <jats:sub>2<\/jats:sub>\n                      affinity or dosage and concurrent PSEs, both overall and separately for mornings, daytimes, and evenings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172510216X_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher antipsychotic dosages were associated with reduced affect variability (Beta [B]\u00a0=\u00a0\u22121.40 [95% confidence interval [CI]: \u22122.52; \u22120.29]) and decreased positive affect stability (B\u00a0=\u00a00.23 [95% CI: 0.04; 0.42]) and intensity (B\u00a0=\u00a0\u22121.11 [95% CI: \u22121.97; \u22120.24]). The latter was also associated with the use of high-affinity D\n                      <jats:sub>2<\/jats:sub>\n                      antagonists versus partial D\n                      <jats:sub>2<\/jats:sub>\n                      agonists (B\u00a0=\u00a012.98 [95% CI: 2.43; 23.53]) and versus low-affinity D\n                      <jats:sub>2<\/jats:sub>\n                      antagonists (B\u00a0=\u00a010.04 [95% CI: 0.59; 19.49]). Other PSEs were not associated with D\n                      <jats:sub>2<\/jats:sub>\n                      affinity\/dosage. Results were relatively consistent across daytimes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172510216X_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Higher antipsychotic dosage and high-affinity D\n                      <jats:sub>2<\/jats:sub>\n                      antagonists were associated with decreased positive affect after remission from FEP, which may partly drive the frequently reported blunting of emotional experience.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s003329172510216x","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:52:03Z","timestamp":1761717123000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Psychological side effects of antipsychotic medication after remission from first-episode psychosis: a HAMLETT ecological momentary assessment study"],"prefix":"10.1017","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-9976","authenticated-orcid":false,"given":"Matej","family":"Djordjevic","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiral S.","family":"Gangadin","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center"},{"name":", University of Groningen, University Medical Center Groningen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieuwe","family":"de Haan","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Jongsma","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center"},{"name":"Center for Transcultural Psychiatry Veldzicht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla P.","family":"Oomen","sequence":"additional","affiliation":[{"name":"Radboud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia J. 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