{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:43:07Z","timestamp":1789494187673,"version":"build-2803163510"},"reference-count":58,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291725102894_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anhedonia is a multidimensional concept, and it is not known which aspects of it are linked to the heterogeneity of treatment responses in major depressive disorder (MDD). We examine the role of anhedonia dimensions in predicting response to antidepressant medication and adjunctive pharmacotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102894_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In CAN-BIND-1, 187 adults with MDD completed the Dimensional Anhedonia Rating Scale (DARS) and the Snaith\u2013Hamilton Pleasure Scale (SHAPS) before undergoing 8\u00a0weeks of treatment with escitalopram. At week 8, 90 nonresponders received adjunctive treatment with aripiprazole for an additional 8\u00a0weeks. Mixed-effects models tested the hobbies, food, social, and sensory subscales and items of DARS and SHAPS as predictors of change in the Montgomery-\u00c5sberg Depression Rating Scale (MADRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102894_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the four DARS subscales, sensory anhedonia predicted a worse treatment outcome with escitalopram (\n                      <jats:italic>b<\/jats:italic>\n                      \u00a0=\u00a01.14, 95%CI 0.08 to 2.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034) as did a three-item SHAPS sensory anhedonia subscale (\n                      <jats:italic>b<\/jats:italic>\n                      \u00a0=\u00a01.50, 95%CI 0.43 to 2.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006). A combined DARS\u2013SHAPS sensory anhedonia subscale complemented the previously reported interest\u2013activity symptom dimension to improve treatment outcome prediction. In contrast, food and social anhedonia dimensions predicted worse outcomes with adjunctive aripiprazole (\n                      <jats:italic>b<\/jats:italic>\n                      \u00a0=\u00a02.52, 95%CI 1.25 to 3.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001;\n                      <jats:italic>b<\/jats:italic>\n                      \u00a0=\u00a02.56, 95%CI 1.16 to 3.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Corresponding SHAPS items showed similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102894_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The inability to enjoy sensory experiences and the lack of interest in food and social activities distinctly predict outcomes with serotonergic versus dopaminergic pharmacotherapy. These findings require replication and extension to other treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291725102894","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:05:53Z","timestamp":1767002753000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Which aspects of anhedonia predict response to pharmacotherapy in major depressive disorder?"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-0546","authenticated-orcid":false,"given":"Rudolf","family":"Uher","sequence":"first","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakina J.","family":"Rizvi","sequence":"additional","affiliation":[{"name":"St. Michael\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-4363","authenticated-orcid":false,"given":"Lena C.","family":"Quilty","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pavlova","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-9150","authenticated-orcid":false,"given":"Abraham","family":"Nunes","sequence":"additional","affiliation":[{"name":"Dalhousie University"},{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-4705","authenticated-orcid":false,"given":"Jane A.","family":"Foster","sequence":"additional","affiliation":[{"name":"McMaster University"},{"name":"UT Southwestern 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