{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:44:42Z","timestamp":1793414682465,"version":"4.5.0"},"reference-count":74,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["80-84800-98-41015"],"award-info":[{"award-number":["80-84800-98-41015"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["636340001"],"award-info":[{"award-number":["636340001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291725102900_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Evidence regarding the effects of antipsychotic medication on cognitive functioning after a first-episode psychosis (FEP) remains inconclusive. This study examined whether dopamine D\n                      <jats:sub>2<\/jats:sub>\n                      receptor occupancy, affinity, and antipsychotic dose are related to cognitive functioning in people in remission from FEP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102900_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      278 remitted FEP participants from the HAMLETT-trial were included. Cognitive functioning was assessed with the Brief Assessment of Cognition in Schizophrenia, 3\u20136\u00a0months after remission. D\n                      <jats:sub>2<\/jats:sub>\n                      receptor occupancy was estimated based on antipsychotic type and dose. Antipsychotics were categorized into partial agonists, or antagonists with high or low D\n                      <jats:sub>2<\/jats:sub>\n                      receptor affinity. Linear regression analyses were performed with inverse probability of treatment weighting to control for differences in characteristics between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102900_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      D\n                      <jats:sub>2<\/jats:sub>\n                      receptor occupancy was negatively related to global cognition (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.18), verbal fluency (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.22), and attention and processing speed (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.17, all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.003). The interaction between daily dose and D\n                      <jats:sub>2<\/jats:sub>\n                      receptor affinity category was significant for global cognition (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0046) and working memory (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0019), but not for verbal fluency after correction for multiple testing (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029). Interactions showed that higher daily dose was related to lower cognitive functioning, with significantly stronger negative effects in high-affinity antagonists compared to other antipsychotics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291725102900_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The current findings underscore the importance of antipsychotic D\n                      <jats:sub>2<\/jats:sub>\n                      receptor occupancy and affinity for cognitive functioning and suggest better cognitive functioning in users of partial agonists and low D\n                      <jats:sub>2<\/jats:sub>\n                      receptor affinity antipsychotics. This can be important when selecting antipsychotics for individuals with FEP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291725102900","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:42:54Z","timestamp":1767350574000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Negative association between cognitive functioning and antipsychotic D\n                    <sub>2<\/sub>\n                    receptor occupancy, affinity, and dose after first episode psychosis"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-0905","authenticated-orcid":false,"given":"Priscilla P.","family":"Oomen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016xsfp80","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University 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