{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:02:22Z","timestamp":1774350142276,"version":"3.50.1"},"reference-count":59,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"unspecified","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726103237_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Romantic relationships are important contexts for substance use and emotional well-being. We tested the hypotheses that (i) genetic predispositions for alcohol consumption would be positively associated with partner substance use, (ii) partner substance use would moderate genetic influences on one\u2019s own alcohol outcomes, and (iii) partner discordance in substance use would be associated with lower emotional well-being and relationship quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103237_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Analyses included 2,357 participants (M\n                      <jats:sub>age<\/jats:sub>\n                      \u00a0=\u00a051.4, 58.2% female) from the Collaborative Studies on the Genetics of Alcoholism. Focal measures included participants\u2019 reports of their own and their current partner\u2019s past-year substance use (frequencies of alcohol use, heavy drinking, drunkenness, cannabis use, and nicotine use), emotional well-being, and relationship quality. Participants\u2019 genetic predispositions were indexed with genome-wide polygenic scores for alcohol consumption (PGS\n                      <jats:sub>Alc<\/jats:sub>\n                      ). Participant\u2013partner substance use discordance was calculated as the difference between the participant\u2019s and their partner\u2019s use for each substance use measure, separately.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103237_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participant PGS\n                      <jats:sub>Alc<\/jats:sub>\n                      was not significantly associated with partners\u2019 perceived substance use. Frequent perceived partner alcohol use and heavy drinking significantly amplified the association between PGS\n                      <jats:sub>Alc<\/jats:sub>\n                      and alcohol use or drunkenness. Frequent perceived partner drunkenness and cannabis use significantly attenuated the association between PGS\n                      <jats:sub>Alc<\/jats:sub>\n                      and heavy drinking or frequency of alcohol use. Participant\u2013partner discordance for several substance use measures was significantly associated with lower emotional well-being and relationship quality, controlling for participant and partner substance use main effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103237_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results highlight the importance of partner substance use in etiological models of alcohol use, emotional health outcomes, and relationship quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726103237","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:43:36Z","timestamp":1774341816000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9405-367X","authenticated-orcid":false,"given":"Megan E.","family":"Cooke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-1001","authenticated-orcid":false,"given":"Sally 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