{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:04:58Z","timestamp":1791353098300,"version":"4.3.1"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"unspecified","delay-in-days":54,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal depressive symptoms during pregnancy have consequences for offspring brain development, likely mediated via biological signals. However, gestational biological correlates of maternal depression may differ depending on childhood maltreatment (CM) history. We investigated the association of maternal depressive symptoms in pregnancy and CM history with newborn global white matter microstructure. In a sample of\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a090 mother\u2013infant dyads from two cohorts, maternal depressive symptoms were assessed with the Edinburgh Postnatal Depression Scale. CM was assessed with the Childhood Trauma Questionnaire or the Adverse Childhood Experiences scale. Diffusion-weighted imaging was performed in the infants within 90\u00a0days of birth. Fiber profiles of fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) were determined, and a global mean for each metric was computed. In adjusted models, there was a significant interaction effect of maternal depression and CM on newborn global FA (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a0\u22120.523,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.029) and RD (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a00.590,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.014) but not AD (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a00.367,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.120). In infants of women with CM history, maternal depressive symptoms were correlated negatively with FA and positively with RD. In contrast, infants of women without CM exhibited the reverse pattern of associations between depressive symptoms and diffusion metrics. These findings suggest that the impact of prenatal exposures, such as maternal depressive symptoms, on offspring brain development may be conditional on the presence or absence of maltreatment history. These findings highlight the importance of assessing trauma history and monitoring psychosocial well-being during pregnancy.\n                  <\/jats:p>","DOI":"10.1017\/s0033291726103468","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:57:26Z","timestamp":1771916246000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-7206","authenticated-orcid":false,"given":"Nora K.","family":"Moog","sequence":"first","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin"},{"name":"Heidelberg 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M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien A.","family":"Fair","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-5913","authenticated-orcid":false,"given":"Madalina E.","family":"Tivarus","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Entringer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin"},{"name":"University of California Irvine, School of Medicine"},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathik 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e51"}}