{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:56:50Z","timestamp":1789401410081,"version":"build-2803163510"},"reference-count":84,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"unspecified","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071506"],"award-info":[{"award-number":["82071506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201692"],"award-info":[{"award-number":["82201692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202406370144"],"award-info":[{"award-number":["202406370144"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Sant\u00e9","doi-asserted-by":"publisher","award":["FRQS 366934"],"award-info":[{"award-number":["FRQS 366934"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726103869_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Working memory (WM) impairment is a core cognitive deficit in schizophrenia, associated with dysfunction of large-scale brain networks, particularly the triple-network system comprising the default mode, frontoparietal, and salience networks. Given the role of environmental risks like childhood trauma (CT) in cognitive deficits, we investigated whether trauma relates to altered triple-network flexibility and WM in schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103869_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 190 patients with schizophrenia (SZ) and 117 healthy controls (HCs). Among them, 162 SZ and 99 HCs underwent\n                      <jats:italic>n<\/jats:italic>\n                      -back task-based functional magnetic resonance imaging. We computed temporal variability (TV) in the triple-network connectivity, defining \u0394TV as the change between 0-back and 2-back conditions. Subgroup comparisons of \u0394TV were conducted within each group based on trauma status. Associations of \u0394TV with WM performance and clinical symptoms were examined in SZ, followed by mediation analyses testing whether \u0394TV mediates the relationship between trauma and WM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103869_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among HCs, individuals with childhood trauma showed reduced \u0394TV across triple-network connections, whereas no such differences appeared in SZ. In SZ, greater \u0394TV within the frontoparietal network (FPN) was correlated with lower positive symptom severity (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.211,\n                      <jats:italic>p<\/jats:italic>\n                      -fdr\u00a0=\u00a00.046) and better\n                      <jats:italic>n<\/jats:italic>\n                      -back target accuracy (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.303,\n                      <jats:italic>p<\/jats:italic>\n                      -fdr\u00a0=\u00a00.002). Furthermore, \u0394TV within the FPN partially mediated the association between trauma and\n                      <jats:italic>n<\/jats:italic>\n                      -back accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103869_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight the central role of FPN flexibility in mediating childhood trauma\u2019s effect on working memory in schizophrenia. This outlines a key pathway through which an early environmental risk (trauma) translates into cognitive and clinical manifestations in schizophrenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726103869","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:28:54Z","timestamp":1775550534000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma"],"prefix":"10.1017","volume":"56","author":[{"given":"Danqing","family":"Huang","sequence":"first","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhening","family":"Liu","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Tan","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Sopodenkiewicz","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawei","family":"Liu","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-2136","authenticated-orcid":false,"given":"Yicheng","family":"Long","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-7182","authenticated-orcid":false,"given":"Lena","family":"Palaniyappan","sequence":"additional","affiliation":[{"name":"McGill University"},{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"S0033291726103869_r45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1808803"},{"key":"S0033291726103869_r60","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00137"},{"key":"S0033291726103869_r68","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.07.020"},{"key":"S0033291726103869_r48","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.748372"},{"key":"S0033291726103869_r61","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01197-x"},{"key":"S0033291726103869_r53","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00370-9"},{"key":"S0033291726103869_r72","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04216-6"},{"key":"S0033291726103869_r51","article-title":"The early longitudinal course of cognitive deficits in schizophrenia","volume":"75","author":"Nuechterlein","year":"2014","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0033291726103869_r27","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2017.1321106"},{"key":"S0033291726103869_r57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"S0033291726103869_r63","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-010-0197-8"},{"key":"S0033291726103869_r76","article-title":"DPABI: Data Processing and Analysis for (resting-state)","volume":"14","author":"Yan","year":"2016","journal-title":"Brain Imaging. 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