{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:45:34Z","timestamp":1785415534144,"version":"3.56.0"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"unspecified","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["119525"],"award-info":[{"award-number":["119525"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["136947"],"award-info":[{"award-number":["136947"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011021","name":"Sunnybrook Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020895","name":"Temerty Faculty of Medicine, University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726103948_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>C-reactive protein (CRP) has been studied in relation to bipolar disorder (BD) and suicidality independently. Although suicide risk is elevated in youth with BD, little is known about the association of CRP with suicidality in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103948_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      211 youth participated, including 23 BD with lifetime suicide attempts (BD\n                      <jats:sub>SA<\/jats:sub>\n                      ), 45 BD with lifetime non-suicidal self-injury (NSSI; BD\n                      <jats:sub>NSSI<\/jats:sub>\n                      ), 39 BD without lifetime suicide attempt or NSSI (BD\n                      <jats:sub>No-SA\/NSSI<\/jats:sub>\n                      ), and 104 healthy controls (HC). Suicide attempts and NSSI were assessed systematically. Fasting blood samples yielded CRP levels. Primary analyses controlled for age, sex, and body mass index percentile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103948_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRP levels differed across groups (\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>3,204<\/jats:sub>\n                      \u00a0=\u00a03.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02,\n                      <jats:italic>\n                        \u03b7\n                        <jats:sub>p<\/jats:sub>\n                      <\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.05). In post hoc analyses, CRP levels were significantly higher among BD\n                      <jats:sub>SA<\/jats:sub>\n                      (3.44\u00a0\u00b1\u00a06.42\u00a0mg\/L) vs HC (0.81\u00a0\u00b1\u00a00.90\u00a0mg\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and BD\n                      <jats:sub>No-SA\/NSSI<\/jats:sub>\n                      (1.42\u00a0\u00b1\u00a03.31\u00a0mg\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) groups; however, no difference was seen with the BD\n                      <jats:sub>NSSI<\/jats:sub>\n                      group (1.83\u00a0\u00b1\u00a02.22\u00a0mg\/L;\n                      <jats:italic>p\u00a0=\u00a00.12<\/jats:italic>\n                      ). Between-group differences in CRP levels persisted in independent sensitivity analyses controlling for current mood symptoms, lifetime mania score, lifetime smoking, and medications, but not with lifetime depression score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726103948_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Suicide attempts among youth with BD are associated with elevated CRP. Given accessibility of CRP testing, the present findings have potential clinical implications. Larger, longitudinal studies with repeated measures are needed to examine time-varying associations between CRP and suicide risk among youth with BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726103948","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:41:34Z","timestamp":1776069694000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Elevated C-reactive protein is associated with suicide attempts in youth with bipolar disorder"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1547-8791","authenticated-orcid":false,"given":"Dharmayu","family":"Desai","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e71c577","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Addiction and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8371-1585","authenticated-orcid":false,"given":"Mikaela K.","family":"Dimick","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e71c577","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Addiction and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-188X","authenticated-orcid":false,"given":"Kody G.","family":"Kennedy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e71c577","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Addiction and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-292X","authenticated-orcid":false,"given":"Alysha A.","family":"Sultan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e71c577","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Addiction and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Mio","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e71c577","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Addiction and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0340-349X","authenticated-orcid":false,"given":"Benjamin I.","family":"Goldstein","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03e71c577","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Addiction and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"S0033291726103948_r25","doi-asserted-by":"publisher","DOI":"10.1080\/14622200801978722"},{"key":"S0033291726103948_r26","doi-asserted-by":"publisher","DOI":"10.1159\/000343302"},{"key":"S0033291726103948_r38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"S0033291726103948_r42","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415594427"},{"key":"S0033291726103948_r16","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30370-4"},{"key":"S0033291726103948_r45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01393.x"},{"key":"S0033291726103948_r49","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10050718"},{"key":"S0033291726103948_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.11.020"},{"key":"S0033291726103948_r44","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyad063"},{"key":"S0033291726103948_r35","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13351"},{"key":"S0033291726103948_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2018.12.006"},{"key":"S0033291726103948_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.04.038"},{"key":"S0033291726103948_r6","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718003008"},{"key":"S0033291726103948_r20","unstructured":"Government of Canada. (2023). Suicide in Canada: Key statistics (1st ed.). Government of Canada. Available at https:\/\/www.canada.ca\/en\/public-health\/services\/publications\/healthy-living\/suicide-canada-key-statistics-infographic.html. Accessed June 3, 2024."},{"key":"S0033291726103948_r4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.175"},{"key":"S0033291726103948_r5","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13016"},{"key":"S0033291726103948_r10","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790300064008"},{"key":"S0033291726103948_r14","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.22m14693"},{"key":"S0033291726103948_r31","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2329D"},{"key":"S0033291726103948_r33","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11060790"},{"key":"S0033291726103948_r37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105766"},{"key":"S0033291726103948_r39","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537962"},{"key":"S0033291726103948_r9","volume-title":"CDC growth charts: United States","year":"2025"},{"key":"S0033291726103948_r40","first-page":"348","article-title":"Relationship of non-suicidal self-injury and suicide attempt: A psychopathological perspective","volume":"21","author":"Pompili","year":"2015","journal-title":"Journal of Psychopathology"},{"key":"S0033291726103948_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2014.12.024"},{"key":"S0033291726103948_r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.05.003"},{"key":"S0033291726103948_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.11.063"},{"key":"S0033291726103948_r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"S0033291726103948_r1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13030505"},{"key":"S0033291726103948_r29","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180050009"},{"key":"S0033291726103948_r22","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.203"},{"key":"S0033291726103948_r36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.01.007"},{"key":"S0033291726103948_r50","doi-asserted-by":"publisher","DOI":"10.1177\/02698811221093796"},{"key":"S0033291726103948_r28","first-page":"980","article-title":"Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data","volume":"36","author":"Kaufman","year":"1997","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"S0033291726103948_r48","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.675"},{"key":"S0033291726103948_r19","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2012.650"},{"key":"S0033291726103948_r18","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08r04505"},{"key":"S0033291726103948_r32","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.263"},{"key":"S0033291726103948_r43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.05.063"},{"key":"S0033291726103948_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.04.039"},{"key":"S0033291726103948_r8","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.116"},{"key":"S0033291726103948_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"S0033291726103948_r46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00754"},{"key":"S0033291726103948_r3","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2023.656"},{"key":"S0033291726103948_r7","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-009-9482-0"},{"key":"S0033291726103948_r51","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02261-w"},{"key":"S0033291726103948_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.125"},{"key":"S0033291726103948_r47","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.13519"},{"key":"S0033291726103948_r2","doi-asserted-by":"publisher","DOI":"10.1089\/104454603322724850"},{"key":"S0033291726103948_r34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31544-0"},{"key":"S0033291726103948_r11","doi-asserted-by":"publisher","DOI":"10.1177\/1099800418779214"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291726103948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:41:42Z","timestamp":1776069702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291726103948\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":51,"alternative-id":["S0033291726103948"],"URL":"https:\/\/doi.org\/10.1017\/s0033291726103948","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e105"}}