{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:39:36Z","timestamp":1787614776456,"version":"build-2736575974"},"reference-count":107,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"unspecified","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE9212\/1-1 (Project Number 513531314)"],"award-info":[{"award-number":["HE9212\/1-1 (Project Number 513531314)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR5187 (Project Number 442075332)"],"award-info":[{"award-number":["FOR5187 (Project Number 442075332)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. 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Thus, this study investigates associations between brain structure and cortisol responses to psychosocial stress, exploring if hypothalamic\u2013pituitary\u2013adrenal axis reactivity can be predicted from brain morphology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726104103_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study included 291 subjects (157 females, 18\u201362\u00a0years) and consisted of two parts. First, a confirmatory analysis examined associations between specific cortical surface area, thickness, and subcortical volume with stress-induced cortisol increases using Permutation Analysis of Linear Models (PALM). Second, we conducted an exploratory whole-brain vertex-wise analysis, followed by out-of-sample prediction of cortisol increases from structural measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726104103_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found consistent negative associations between cingulate cortex (CC) sub-structures and acute cortisol increases. In PALM- and whole-brain analysis, a smaller surface area of the left rostral and caudal anterior cingulate cortex (cACC), posterior cingulate cortex, and right cACC were associated with higher cortisol stress responses, particularly in males. The left cACC surface area emerged as the most promising predictor in machine learning analyses. Additionally, other fronto-limbic structures were also associated with or predictive of acute cortisol reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726104103_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that cortical and subcortical structural measures, particularly smaller surface areas of the CC, predict acute hormonal stress responses. Notably, the left cACC emerged as the most consistent predictor, emphasizing its important role in stress reactivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726104103","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:29:02Z","timestamp":1775550542000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-3027","authenticated-orcid":false,"given":"Emin","family":"Serin","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin"},{"name":"German Center for Mental Health (DZPG)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1423-354X","authenticated-orcid":false,"given":"Lea 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