{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:15:04Z","timestamp":1778498104056,"version":"3.51.4"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"unspecified","delay-in-days":130,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726104322_sec01\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gambling disorder (GD) involves persistent risky choices despite losses, suggesting impaired impulse control. While static paradigms reveal inhibition deficits in GD, they cannot model dynamic risk-reward escalations during real gambling. This study aims to investigate whether GD involves impaired dynamic impulse control during escalating stakes and to dissociate contributions of subjective risk evaluation and trait impulsivity to this deficit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726104322_sec02\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a sequential gambling task with 83 male patients with GD and 62 matched healthy controls (HCs), this study investigated dynamic impulse control deficits under escalating stakes. We quantified dynamic impulse control via the reward\u2013reaction time (RT) coupling for \u2018continue\u2019 choices (dynamic impulse control index [DICI]) using Bayesian modeling. Risk sensitivity and risk preference were derived from stop\/continue decisions. Trait impulsivity was assessed with the Barratt Impulsiveness Scale (BIS-11). Regression analyses examined the modulation of DICI by risk sensitivity and trait impulsivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726104322_sec03\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with GD exhibited significantly attenuated DICI versus HCs, reflecting failure to increase deliberation with escalating stakes. Computational modeling revealed markedly reduced risk sensitivity in GD despite comparable risk preference. Critically, trait impulsivity positively modulated DICI in HCs but not in GD, indicating pathological decoupling. Risk sensitivity positively predicted DICI in both groups, though significantly weaker in GD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726104322_sec04\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings establish a triadic impairment in GD: (1) attenuated adaptive impulse control during escalation (impaired DICI), (2) deficient subjective risk weighting (reduced sensitivity), and (3) breakdown of impulsivity-based modulation of control. This reveals a dynamic, mechanism-focused pathology beyond static trait models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726104322","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:33:43Z","timestamp":1778495623000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Attenuated dynamic impulse control in risky action under the escalating risk and reward in gambling disorder"],"prefix":"10.1017","volume":"56","author":[{"given":"Gangliang","family":"Zhong","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e141"}}