{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:21:17Z","timestamp":1788394877373,"version":"build-2803163510"},"reference-count":102,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"unspecified","delay-in-days":245,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["30919"],"award-info":[{"award-number":["30919"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726105315_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fluctuations in ovarian hormones are associated with changes in mood and emotional well-being. However, the neural mechanisms linking endocrine states and affective regulation remain poorly understood. We aimed to investigate how endogenous estradiol and progesterone modulate brain representations underlying emotion\u2013action control in healthy young women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105315_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 116 naturally cycling women performed an approach\u2013avoidance task with emotional facial expressions during functional magnetic resonance imaging. Multivoxel pattern analyses were used to examine the neural encoding of emotion\u2013action contingencies, i.e., classifying task conditions from multivariate activation patterns. We then tested whether salivary concentrations of estradiol and progesterone were associated with classification accuracy in various brain regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105315_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants responded more slowly and less accurately when approaching angry faces or avoiding happy ones, reflecting control over automatic emotional tendencies. Multivoxel decoding revealed that task conditions could be reliably distinguished from activation patterns in the lateral frontal pole (FPl), striatum, central insula, dorsal and ventral cerebellum, primary visual cortex, and periaqueductal gray. Importantly, higher progesterone levels were correlated with reduced classification accuracy in the FPl (\n                      <jats:italic>r<\/jats:italic>\n                      =-.26,\n                      <jats:italic>p<\/jats:italic>\n                      =.006) and striatum (\n                      <jats:italic>r<\/jats:italic>\n                      =-.26,\n                      <jats:italic>p<\/jats:italic>\n                      =.007), and lower FPl decodability was linked to poorer mood during the preceding week (\n                      <jats:italic>r<\/jats:italic>\n                      =-.25,\n                      <jats:italic>p<\/jats:italic>\n                      =.011). Moreover, decoding accuracy in the FPl fully mediated the indirect association between progesterone and worse mood (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =7.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105315_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that progesterone-related alterations in frontostriatal affective representations may contribute to mood variation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726105315","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:08:21Z","timestamp":1788394101000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Endogenous progesterone blurs frontostriatal representations of emotion control in healthy young women"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-9216","authenticated-orcid":false,"given":"Maci\u00e0","family":"Buades-Rotger","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Barcelona"},{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4581-438X","authenticated-orcid":false,"given":"Rosamunde","family":"Hendricks","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052g8jq94","id-type":"ROR","asserted-by":"publisher"}],"name":"Autonomous University of Barcelona"},{"id":[{"id":"https:\/\/ror.org\/042nkmz09","id-type":"ROR","asserted-by":"publisher"}],"name":"Hospital del Mar Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0244-2964","authenticated-orcid":false,"given":"Beatrice","family":"Roncarati","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-9715","authenticated-orcid":false,"given":"Marta","family":"Calder\u00f3n-Garc\u00eda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9494-1489","authenticated-orcid":false,"given":"Kaja","family":"Bergmann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-9164","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"P\u00e9rez-Cano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Barcelona"},{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"S0033291726105315_r36","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-017-0935-1"},{"key":"S0033291726105315_r78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2012.11.012"},{"key":"S0033291726105315_r54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.08.053"},{"key":"S0033291726105315_r90","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2013.835862"},{"key":"S0033291726105315_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.106006"},{"key":"S0033291726105315_r17","doi-asserted-by":"publisher","DOI":"10.1027\/1015-5759\/a000150"},{"key":"S0033291726105315_r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.12.009"},{"key":"S0033291726105315_r48","doi-asserted-by":"publisher","DOI":"10.1080\/02699930903485076"},{"key":"S0033291726105315_r42","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-021-01055-2"},{"key":"S0033291726105315_r76","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v048.i02"},{"key":"S0033291726105315_r46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.11.019"},{"key":"S0033291726105315_r74","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.15003"},{"key":"S0033291726105315_r85","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2020.100856"},{"key":"S0033291726105315_r51","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.014"},{"key":"S0033291726105315_r44","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01010-9"},{"key":"S0033291726105315_r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2024.108896"},{"key":"S0033291726105315_r89","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2024.107111"},{"key":"S0033291726105315_r98","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsaa057"},{"key":"S0033291726105315_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.04.014"},{"key":"S0033291726105315_r33","first-page":"822","article-title":"From classical methods to generative models: Tackling the unreliability of neuroscientific measures in mental health research","volume":"8","author":"Haines","year":"2023","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"S0033291726105315_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.013"},{"key":"S0033291726105315_r37","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-024-00224-2"},{"key":"S0033291726105315_r100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121263"},{"key":"S0033291726105315_r88","doi-asserted-by":"publisher","DOI":"10.1080\/01973533.2015.1049351"},{"key":"S0033291726105315_r32","doi-asserted-by":"publisher","DOI":"10.1037\/met0000674"},{"key":"S0033291726105315_r34","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00088"},{"key":"S0033291726105315_r82","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902940107"},{"key":"S0033291726105315_r26","doi-asserted-by":"publisher","DOI":"10.1177\/0956797620916786"},{"key":"S0033291726105315_r99","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240596"},{"key":"S0033291726105315_r68","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2023.105406"},{"key":"S0033291726105315_r28","doi-asserted-by":"publisher","DOI":"10.1177\/2515245919847202"},{"key":"S0033291726105315_r40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0794-24.2024"},{"key":"S0033291726105315_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2024.107103"},{"key":"S0033291726105315_r73","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105425"},{"key":"S0033291726105315_r97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237032"},{"key":"S0033291726105315_r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ausmj.2018.03.002"},{"key":"S0033291726105315_r64","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02693-4"},{"key":"S0033291726105315_r13","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsab061"},{"key":"S0033291726105315_r52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33580-7"},{"key":"S0033291726105315_r101","article-title":"Cingulate and frontopolar cortical projections to the cerebellar vermis support prolonged reaction time in identifying negative emotional scenes in women","author":"Wong","year":"2025","journal-title":"medRxiv"},{"key":"S0033291726105315_r35","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000164"},{"key":"S0033291726105315_r56","article-title":"Improving emotion control in social anxiety by targeting rhythmic brain activity","author":"Meijer","year":"2024","journal-title":"The Journal of Neuroscience"},{"key":"S0033291726105315_r1","first-page":"95","article-title":"Versi\u00f3n breve en espa\u00f1ol del cuestionario POMS para deportistas adultos y poblaci\u00f3n general. [Abbreviated version in Spanish of the POMS questionnaire for adult athletes and general population.]","volume":"22","author":"Andrade","year":"2013","journal-title":"Revista de Psicolog\u00eda Del Deporte"},{"key":"S0033291726105315_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.02.007"},{"key":"S0033291726105315_r58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119631"},{"key":"S0033291726105315_r87","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(26)00717-8"},{"key":"S0033291726105315_r11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2048-19.2020"},{"key":"S0033291726105315_r83","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2025.05.025"},{"key":"S0033291726105315_r72","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105977"},{"key":"S0033291726105315_r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2024.101160"},{"key":"S0033291726105315_r79","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq191"},{"key":"S0033291726105315_r57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.11.004"},{"key":"S0033291726105315_r31","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-020-02124-4"},{"key":"S0033291726105315_r5","article-title":"Dose-dependent effects of estrogen on prediction error related neural activity in the nucleus accumbens of healthy young women","volume":"237","author":"Bayer","year":"2019","journal-title":"Psychopharmacology"},{"key":"S0033291726105315_r47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.11.003"},{"key":"S0033291726105315_r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.033"},{"key":"S0033291726105315_r102","doi-asserted-by":"publisher","DOI":"10.1093\/psyrad\/kkaf009"},{"key":"S0033291726105315_r84","doi-asserted-by":"publisher","DOI":"10.1002\/da.22760"},{"key":"S0033291726105315_r65","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-022-01459-4"},{"key":"S0033291726105315_r14","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01706"},{"key":"S0033291726105315_r61","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2018.79.171"},{"key":"S0033291726105315_r50","doi-asserted-by":"publisher","DOI":"10.1037\/met0000381"},{"key":"S0033291726105315_r20","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105207"},{"key":"S0033291726105315_r15","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-019-0152-7"},{"key":"S0033291726105315_r43","doi-asserted-by":"publisher","DOI":"10.1177\/0956797619851753"},{"key":"S0033291726105315_r93","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1715-07.2007"},{"key":"S0033291726105315_r70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2021.01.012"},{"key":"S0033291726105315_r75","doi-asserted-by":"publisher","DOI":"10.1177\/25152459221095827"},{"key":"S0033291726105315_r24","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_02297"},{"key":"S0033291726105315_r91","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsac035"},{"key":"S0033291726105315_r69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"S0033291726105315_r66","doi-asserted-by":"publisher","DOI":"10.1080\/00273170802034844"},{"key":"S0033291726105315_r3","first-page":"1","article-title":"Whole-brain dynamics across the menstrual cycle: The role of hormonal fluctuations and age in healthy women","volume":"2","author":"Avila-Varela","year":"2024","journal-title":"npj Women\u2019s Health"},{"key":"S0033291726105315_r95","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0107-15.2016"},{"key":"S0033291726105315_r16","first-page":"463","article-title":"Manifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems","volume":"10","author":"Busch","year":"2025","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"S0033291726105315_r67","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0435-3"},{"key":"S0033291726105315_r80","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14856"},{"key":"S0033291726105315_r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.10.008"},{"key":"S0033291726105315_r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105994"},{"key":"S0033291726105315_r49","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1522-21.2021"},{"key":"S0033291726105315_r81","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-021-00908-7"},{"key":"S0033291726105315_r53","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"S0033291726105315_r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104398"},{"key":"S0033291726105315_r86","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4811-09.2010"},{"key":"S0033291726105315_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104747"},{"key":"S0033291726105315_r55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04492-9"},{"key":"S0033291726105315_r4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03679-x"},{"key":"S0033291726105315_r94","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00413"},{"key":"S0033291726105315_r92","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.06.009"},{"key":"S0033291726105315_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jesp.2022.104382"},{"key":"S0033291726105315_r12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40666-3"},{"key":"S0033291726105315_r39","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae215"},{"key":"S0033291726105315_r10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59600"},{"key":"S0033291726105315_r71","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1400074"},{"key":"S0033291726105315_r27","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088099"},{"key":"S0033291726105315_r96","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsx092"},{"key":"S0033291726105315_r77","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.02.006"},{"key":"S0033291726105315_r63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2020.100215"},{"key":"S0033291726105315_r38","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02066-2"},{"key":"S0033291726105315_r59","first-page":"1688","article-title":"Dissociable forms of uncertainty-driven representational change across the human brain","volume":"39","author":"Nassar","year":"2019","journal-title":"Journal of Neuroscience"},{"key":"S0033291726105315_r60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.11.012"},{"key":"S0033291726105315_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105802"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291726105315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:08:24Z","timestamp":1788394104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291726105315\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":102,"alternative-id":["S0033291726105315"],"URL":"https:\/\/doi.org\/10.1017\/s0033291726105315","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e263"}}