{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:05:27Z","timestamp":1789452327112,"version":"build-2803163510"},"reference-count":55,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"unspecified","delay-in-days":257,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012576"],"award-info":[{"award-number":["2025A1515012576"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726105595_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although recent stressful life events (SLEs) have been implicated as a risk factor for schizophrenia, prospective evidence and the underlying immunometabolic mechanisms remain unclear. This study investigated the association between recent SLEs and schizophrenia risk and explored the potential mediating role of immunometabolic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105595_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were drawn from the UK Biobank prospective cohort. Cox proportional hazards models, linear mixed-effects models, and mediation analyses were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105595_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 493,294 participants (mean [SD] age, 56.55 [8.09] years; 45.56% male) free of schizophrenia at baseline, among whom 492 schizophrenia cases were identified over a median follow-up of 13.91\u00a0years. Exposure to any recent SLEs was associated with a 49% higher risk of schizophrenia, with evidence of a dose\u2013response relationship (e.g. highest SLE score group: HR, 7.15, 95% CI: 5.74\u20139.11). Among individual SLE types, \u2018serious illness, injury, or assault to yourself\u2019 and \u2018financial difficulties\u2019 showed the strongest associations with schizophrenia risk. Recent SLEs were associated with alterations in multiple immunometabolic markers, several of which were also significantly associated with schizophrenia risk. Mediation analyses indicated that specific immunometabolic markers (e.g. C-reactive protein and degree of unsaturation) partially mediated the association between recent SLEs and subsequent schizophrenia risk, with proportion mediated estimates of 9.0% and 11.7%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105595_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort of predominantly middle-aged and older adults, recent SLEs were associated with increased subsequent schizophrenia risk. Immunometabolic pathways may partially underlie this association, supporting further investigation of integrated psychosocial and biological approaches to schizophrenia risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726105595","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:50:55Z","timestamp":1789451455000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Recent stressful life events, immunometabolic markers, and risk of schizophrenia: A prospective cohort study"],"prefix":"10.1017","volume":"56","author":[{"given":"Yannan","family":"Guo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0064kty71","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Public Health, Sun Yatsen University"},{"id":[{"id":"https:\/\/ror.org\/0064kty71","id-type":"ROR","asserted-by":"publisher"}],"name":"Sun Yat-sen 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e273"}}