{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:42:56Z","timestamp":1792406576311,"version":"4.4.0"},"reference-count":101,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"unspecified","delay-in-days":291,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82441007, and 82120108014"],"award-info":[{"award-number":["82441007, and 82120108014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401796"],"award-info":[{"award-number":["82401796"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726105789_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune-inflammatory dysregulation and cortical structural vulnerability have been increasingly implicated in major depressive disorder (MDD). However, how they interact with each other, and whether immune heterogeneity in MDD is systematically organized by structural networks, remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105789_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genome-wide association studies data of MDD, gray matter volume (GMV) phenotypes, and 19 immune-related traits were utilized to assess causal relationships. A prospective cohort comprising 122 patients with MDD and 66 healthy controls underwent structural magnetic resonance imaging and assessment of 40 inflammatory and immune-related markers. Individualized structural covariance network analysis, machine-learning approaches, and survival analyses were used to identify neurobiological subtypes and evaluate treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105789_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genetically predicted MDD was associated with lower levels of circulating IGF-1 (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u00a0=\u00a00.013). Levels of IL-5 and leptin were negatively associated with GMV alterations in the right cingulate gyrus and bilateral putamen, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u00a0&lt;\u00a00.05). Structural covariance abnormalities were predominantly localized to connectivity between the default mode and limbic networks and within the limbic network in MDD, and they were classified into a hypoconnectivity subtype (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049) and a hyperconnectivity subtype (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a073). The hypoconnectivity subtype exhibited greater anxiety and anhedonia symptoms, whereas the hyperconnectivity subtype showed broadly elevated inflammatory and immune state and achieved antidepressant response more rapidly during follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105789_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports a bidirectional immune\u2013brain framework in MDD and suggests that structure-derived subtypes classify different immune signaling heterogeneity, which may provide a biologically informed basis for stratification and prognosis in MDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726105789","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:57:50Z","timestamp":1792403870000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Structural network alterations and peripheral immune-inflammatory dysregulation define distinct subtypes of major depressive disorder with prognostic implications"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-356X","authenticated-orcid":false,"given":"Wei","family":"Du","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-5796","authenticated-orcid":false,"given":"Minlan","family":"Yuan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Gao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0075-9444","authenticated-orcid":false,"given":"Haoran","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Xue","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guyue","family":"Lei","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8897-8226","authenticated-orcid":false,"given":"Erqing","family":"Liao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-9239","authenticated-orcid":false,"given":"Daniel J.","family":"Hauke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Kuang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7930-4213","authenticated-orcid":false,"given":"Danlin","family":"Shen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-581X","authenticated-orcid":false,"given":"Hongru","family":"Zhu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DIRECT Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-1769","authenticated-orcid":false,"given":"Su","family":"Lui","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-9577","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"S0033291726105789_r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchp.2025.100629"},{"key":"S0033291726105789_r55","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31948-2"},{"key":"S0033291726105789_r7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-080621-045153"},{"key":"S0033291726105789_r39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07469-y"},{"key":"S0033291726105789_r44","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3604"},{"key":"S0033291726105789_r41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz469"},{"key":"S0033291726105789_r42","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.167"},{"key":"S0033291726105789_r51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.01.043"},{"key":"S0033291726105789_r40","article-title":"Blood biomarkers in patients with Parkinson\u2019s disease: A review in context of Anesthetic care","volume":"13","author":"Joo","year":"2023","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"S0033291726105789_r28","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01766-y"},{"key":"S0033291726105789_r57","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.006"},{"key":"S0033291726105789_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.04.014"},{"key":"S0033291726105789_r56","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01618-3"},{"key":"S0033291726105789_r47","doi-asserted-by":"publisher","DOI":"10.1002\/da.23260"},{"key":"S0033291726105789_r69","first-page":"22","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0033291726105789_r53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.01.025"},{"key":"S0033291726105789_r81","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.04.026"},{"key":"S0033291726105789_r84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2025.129461"},{"key":"S0033291726105789_r85","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110108"},{"key":"S0033291726105789_r91","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291724003283"},{"key":"S0033291726105789_r72","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415460"},{"key":"S0033291726105789_r25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062561"},{"key":"S0033291726105789_r37","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291725100664"},{"key":"S0033291726105789_r48","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.95"},{"key":"S0033291726105789_r59","doi-asserted-by":"publisher","DOI":"10.1201\/9781315533247"},{"key":"S0033291726105789_r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2025.103794"},{"key":"S0033291726105789_r63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17419-7"},{"key":"S0033291726105789_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.12.045"},{"key":"S0033291726105789_r77","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1242614"},{"key":"S0033291726105789_r94","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01550-z"},{"key":"S0033291726105789_r90","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"Journal of Neurophysiology"},{"key":"S0033291726105789_r1","first-page":"3","article-title":"Growth hormone and IGF-1 actions in the brain and neuropsychiatric diseases","volume":"41","author":"Aguiar-Oliveira","year":"2026","journal-title":"Physiology (Bethesda, MD)"},{"key":"S0033291726105789_r66","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac037"},{"key":"S0033291726105789_r98","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13614"},{"key":"S0033291726105789_r6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0673-21.2021"},{"key":"S0033291726105789_r30","doi-asserted-by":"publisher","DOI":"10.23970\/AHRQEPCLIBRARYDEPRESSION"},{"key":"S0033291726105789_r24","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-025-03231-8"},{"key":"S0033291726105789_r17","first-page":"E1041","article-title":"Targeted knockout of a chemokine-like gene increases anxiety and fear responses","volume":"115","author":"Choi","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"S0033291726105789_r31","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1691"},{"key":"S0033291726105789_r36","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723000302"},{"key":"S0033291726105789_r79","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2021.103"},{"key":"S0033291726105789_r82","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02964-x"},{"key":"S0033291726105789_r95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.06.013"},{"key":"S0033291726105789_r21","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"S0033291726105789_r10","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0255-x"},{"key":"S0033291726105789_r23","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04442-y"},{"key":"S0033291726105789_r99","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06665-w"},{"key":"S0033291726105789_r100","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00378"},{"key":"S0033291726105789_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.024"},{"key":"S0033291726105789_r68","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae318"},{"key":"S0033291726105789_r92","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2021-001102"},{"key":"S0033291726105789_r101","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2026.02.005"},{"key":"S0033291726105789_r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2024.01.026"},{"key":"S0033291726105789_r18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043231"},{"key":"S0033291726105789_r74","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"S0033291726105789_r76","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2025.1645437"},{"key":"S0033291726105789_r83","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2026.1828777"},{"key":"S0033291726105789_r70","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2025.06.030"},{"key":"S0033291726105789_r58","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01323-9"},{"key":"S0033291726105789_r22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601"},{"key":"S0033291726105789_r93","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12835"},{"key":"S0033291726105789_r4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070459"},{"key":"S0033291726105789_r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110534"},{"key":"S0033291726105789_r16","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.167"},{"key":"S0033291726105789_r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2024.05.015"},{"key":"S0033291726105789_r33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.009"},{"key":"S0033291726105789_r61","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-026-02287-z"},{"key":"S0033291726105789_r71","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.01.008"},{"key":"S0033291726105789_r80","doi-asserted-by":"publisher","DOI":"10.1159\/000518351"},{"key":"S0033291726105789_r29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262110362"},{"key":"S0033291726105789_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.01.023"},{"key":"S0033291726105789_r46","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.88"},{"key":"S0033291726105789_r75","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01074-w"},{"key":"S0033291726105789_r87","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1013933"},{"key":"S0033291726105789_r73","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02526-4"},{"key":"S0033291726105789_r97","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001926"},{"key":"S0033291726105789_r34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00475"},{"key":"S0033291726105789_r49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262010092"},{"key":"S0033291726105789_r13","doi-asserted-by":"publisher","DOI":"10.1093\/psyrad\/kkac005"},{"key":"S0033291726105789_r86","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900390116"},{"key":"S0033291726105789_r3","doi-asserted-by":"publisher","DOI":"10.1159\/000513093"},{"key":"S0033291726105789_r64","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3591"},{"key":"S0033291726105789_r89","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-022-01412-9"},{"key":"S0033291726105789_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.12.013"},{"key":"S0033291726105789_r20","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01738-y"},{"key":"S0033291726105789_r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.01.017"},{"key":"S0033291726105789_r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2026.121259"},{"key":"S0033291726105789_r54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.12.002"},{"key":"S0033291726105789_r65","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-025-02060-6"},{"key":"S0033291726105789_r43","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0574-2"},{"key":"S0033291726105789_r96","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70319"},{"key":"S0033291726105789_r78","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70215"},{"key":"S0033291726105789_r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.11.003"},{"key":"S0033291726105789_r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.11.029"},{"key":"S0033291726105789_r15","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqaa028"},{"key":"S0033291726105789_r52","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2024.41"},{"key":"S0033291726105789_r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"S0033291726105789_r60","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-03031-6"},{"key":"S0033291726105789_r9","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01687-4"},{"key":"S0033291726105789_r67","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02736-w"},{"key":"S0033291726105789_r88","first-page":"135","article-title":"Identifying subgroups of major depressive disorder using brain structural covariance networks and mapping of associated clinical and cognitive variables","volume":"1","author":"Yang","year":"2021","journal-title":"Biological Psychiatry: Global Open Science"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291726105789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:57:54Z","timestamp":1792403874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291726105789\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":101,"alternative-id":["S0033291726105789"],"URL":"https:\/\/doi.org\/10.1017\/s0033291726105789","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e340"}}