{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:51:53Z","timestamp":1791273113731,"version":"4.1.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"unspecified","delay-in-days":278,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502501"],"award-info":[{"award-number":["82502501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S003329172610590X_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescent major depressive disorder (MDD) has been associated with cortical structural abnormalities. However, whether these structural changes correlate with gene expression profiles remains unclear. Here, we investigated the cortical similarity network alterations and the associated transcriptional patterns in adolescents with MDD using a novel Morphometric Inverse Divergence (MIND) network model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172610590X_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using structural images from 174 adolescents with MDD and 82 healthy controls (HCs), we constructed individual MIND networks based on multiple morphological features. We compared regional MIND between groups and developed machine learning models to assess the potential of MIND for distinguishing patients from HCs. Spatial associations between MIND differences and gene expression profiles were assessed using partial least squares regression, followed by gene enrichment analyses to identify associated biological pathways, cell types, and developmental trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172610590X_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regional MIND abnormalities in adolescent MDD patients were primarily located in the orbitofrontal cortex, as well as in sensorimotor and visual network regions. Using MIND features, the optimal machine learning model achieved a high area under the curve (AUC) of 0.824 and generalized well to the external independent dataset (AUC\u00a0=\u00a00.724). MIND changes were associated with gene expression related to synaptic signaling, neurodevelopment, metabolism, and specific cell types. Developmental trajectory analysis suggested distinct, region-specific susceptibility windows for adolescent MDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S003329172610590X_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By linking MIND network alterations and transcriptional expression profiles, this study provides new insights into the neural basis and associated molecular mechanisms underlying adolescent MDD and underscores the diagnostic potential of MIND.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s003329172610590x","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:04:21Z","timestamp":1791270261000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional signatures associated with cortical similarity network changes in adolescents with major depressive disorder"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-9747","authenticated-orcid":false,"given":"Baolin","family":"Wu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007mrxy13","id-type":"ROR","asserted-by":"publisher"}],"name":"West China Hospital of Sichuan 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e314"}}