{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:05:11Z","timestamp":1790766311923,"version":"4.1.0"},"reference-count":63,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726105935_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ADHD has been associated with BMI, across the lifespan. A possible mechanism linking ADHD and BMI is binge eating symptoms. Previous research has found associations between ADHD, binge eating symptoms, and BMI. However, the role of genetic and environmental influences on these associations remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105935_sec2\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We utilized data from the Twins Early Development Study, comprising 4,363 monozygotic and 8,575 dizygotic twin pairs. ADHD symptoms in childhood and adolescence were assessed using parent-reported questionnaires. Adult ADHD symptoms were measured using both self-report and parent-report questionnaires. Phenotypic mediation models examined whether binge eating symptoms mediated the association between ADHD and BMI, without controlling for genetic confounding. Subsequently, the etiological architecture underlying the associations among the three traits across childhood, adolescence, and adulthood were investigated by incorporating genetic and environmental influences into the models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105935_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Binge eating symptoms significantly mediated the association between ADHD symptoms and BMI in both adolescence and adulthood. However, these mediation effects were no longer present once genetic and environmental influences were incorporated into the models. The best-fitting model in childhood, adolescence, and adulthood was Cholesky decomposition models, where covariance between traits was explained by shared etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726105935_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This twin study reveals shared liability across ADHD, binge eating symptoms, and BMI. The mediating role of binge eating symptoms in the relationship between ADHD symptoms and BMI was largely confounded by shared genetic influences. Intervention strategies could focus more on common underlying behavioral and self-regulatory mechanisms across these traits, as well as placing more emphasis on symptom patterns within families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726105935","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:32:17Z","timestamp":1790764337000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of binge eating symptoms in the association between ADHD and BMI: a twin study"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0616-5715","authenticated-orcid":false,"given":"Yuan","family":"You","sequence":"first","affiliation":[{"name":"King\u2019s College London, Social, Genetic & Developmental Psychiatry Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-3499","authenticated-orcid":false,"given":"Tom A.","family":"McAdams","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Social, Genetic & Developmental Psychiatry Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-9429","authenticated-orcid":false,"given":"Olakunle","family":"Oginni","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kk7td41","id-type":"ROR","asserted-by":"publisher"}],"name":"Cardiff University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyu","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-5070","authenticated-orcid":false,"given":"Moritz","family":"Herle","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Social, Genetic & Developmental Psychiatry Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.S.","family":"Zavos","sequence":"additional","affiliation":[{"name":"King\u2019s College London, Institute of Psychiatry, Psychology & Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"S0033291726105935_r8","doi-asserted-by":"publisher","DOI":"10.1201\/b10790"},{"key":"S0033291726105935_r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.11.005"},{"key":"S0033291726105935_r48","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S68763"},{"key":"S0033291726105935_r50","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/3.2.119"},{"key":"S0033291726105935_r51","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2019.56"},{"key":"S0033291726105935_r29","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(24)00186-X"},{"key":"S0033291726105935_r47","doi-asserted-by":"publisher","DOI":"10.3390\/bs13060499"},{"key":"S0033291726105935_r5","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"S0033291726105935_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.09.031"},{"key":"S0033291726105935_r37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.08.020"},{"key":"S0033291726105935_r3","first-page":"267","volume-title":"Proceedings of the second international symposium on information theory","author":"Akaike","year":"1973"},{"key":"S0033291726105935_r60","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.31.25321397"},{"key":"S0033291726105935_r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.12.017"},{"key":"S0033291726105935_r7","doi-asserted-by":"publisher","DOI":"10.1038\/nrg932"},{"key":"S0033291726105935_r52","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-018-9941-z"},{"key":"S0033291726105935_r65","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291170"},{"key":"S0033291726105935_r31","first-page":"195","volume-title":"Statistical and methodological myths and urban legends: Doctrine, verity, and fable in the organizational and social sciences","author":"Landis","year":"2009"},{"key":"S0033291726105935_r35","doi-asserted-by":"publisher","DOI":"10.1002\/erv.3177"},{"key":"S0033291726105935_r56","unstructured":"Steiger, J. 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