{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:52:24Z","timestamp":1791276744475,"version":"4.1.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"unspecified","delay-in-days":278,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA060362"],"award-info":[{"award-number":["R21DA060362"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA057289"],"award-info":[{"award-number":["R01DA057289"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291726106163_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psilocybin use has increased in the US alongside promising therapeutic potential for depression, raising concerns that individuals may forgo conventional mental health treatment for unsupervised psilocybin use. However, no nationally representative studies have examined whether psilocybin use is associated with differential treatment utilization or perceived unmet need for mental health care among individuals with depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726106163_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 6,793 individuals aged \u2265 12\u00a0years with a past-year major depressive episode (MDE) from the 2024 National Survey on Drug Use and Health, a nationally representative survey of the noninstitutionalized US population. Sociodemographic and substance use characteristics were first compared by past-year psilocybin use. We then examined associations between past-year psilocybin use and eight past-year mental health treatment outcomes using Poisson regression, adjusting for sociodemographic characteristics, other past-year substance use, psychotherapeutic prescription misuse, and alcohol use disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726106163_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among individuals with past-year MDE, an estimated 7.3% (95% CI: 6.4\u20138.3) used psilocybin in the past year. In multivariable models, psilocybin use was not associated with any mental health treatment utilization, including outpatient, inpatient, or telehealth treatment; prescription medication use for mental health; seeing a doctor for depressive feelings; or prescription medication use for depressive feelings. However, psilocybin use was associated with greater perceived unmet treatment need (52.0% vs. 33.9%; aPR\u00a0=\u00a01.44; 95% CI: 1.04\u20132.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291726106163_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings suggest that psilocybin use among individuals with depression co-occurs with perceived unmet need for conventional mental health care but is not associated with lower utilization of any conventional mental health treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291726106163","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:18:00Z","timestamp":1791274680000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Psilocybin use, mental health treatment utilization, and unmet treatment need among US individuals with depression"],"prefix":"10.1017","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9185-6168","authenticated-orcid":false,"given":"Avery Chan","family":"Eun","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San Diego School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1451-258X","authenticated-orcid":false,"given":"Kevin H.","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San Diego School of Medicine"},{"id":[{"id":"https:\/\/ror.org\/046rm7j60","id-type":"ROR","asserted-by":"publisher"}],"name":"David Geffen School of Medicine at UCLA"},{"id":[{"id":"https:\/\/ror.org\/046rm7j60","id-type":"ROR","asserted-by":"publisher"}],"name":"National Clinician Scholars Program at UCLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-9415","authenticated-orcid":false,"given":"Joseph J.","family":"Palamar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0190ak572","id-type":"ROR","asserted-by":"publisher"}],"name":"NYU Grossman School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"S0033291726106163_r28","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2024.1653"},{"key":"S0033291726106163_r14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206443"},{"key":"S0033291726106163_r5","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2025.2511750"},{"key":"S0033291726106163_r11","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.13393"},{"key":"S0033291726106163_r8","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4771-x"},{"key":"S0033291726106163_r2","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"S0033291726106163_r10","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-021-02668-2"},{"key":"S0033291726106163_r15","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513"},{"key":"S0033291726106163_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2024.111086"},{"key":"S0033291726106163_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.12.006"},{"key":"S0033291726106163_r18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063972"},{"key":"S0033291726106163_r1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2025.2511752"},{"key":"S0033291726106163_r12","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3285"},{"key":"S0033291726106163_r6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2026.1952"},{"key":"S0033291726106163_r9","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-025-00563-0"},{"key":"S0033291726106163_r20","doi-asserted-by":"publisher","DOI":"10.1177\/15404153211057563"},{"key":"S0033291726106163_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.05.044"},{"key":"S0033291726106163_r4","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2024.2376755"},{"key":"S0033291726106163_r7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1224551"},{"key":"S0033291726106163_r3","doi-asserted-by":"publisher","DOI":"10.1089\/psymed.2023.0036"},{"key":"S0033291726106163_r17","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.3038"},{"key":"S0033291726106163_r19","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.20190028"},{"key":"S0033291726106163_r24","unstructured":"Substance Abuse and Mental Health Services Administration. (2025). Key Substance Use and Mental Health Indicators in the United States: Results from the 2024 National Survey on Drug Use and Health (HHS Publication No. PEP25\u201307-007, NSDUH Series H-60). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https:\/\/www.samhsa.gov\/data\/data-we-collect\/nsduh-national-surveydrug-use-and-health\/national-releases"},{"key":"S0033291726106163_r16","doi-asserted-by":"publisher","DOI":"10.1111\/add.15789"},{"key":"S0033291726106163_r26","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20251343"},{"key":"S0033291726106163_r23","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-03145"},{"key":"S0033291726106163_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2022.107343"},{"key":"S0033291726106163_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2023.104001"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291726106163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:18:03Z","timestamp":1791274683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291726106163\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"alternative-id":["S0033291726106163"],"URL":"https:\/\/doi.org\/10.1017\/s0033291726106163","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e316"}}